Intrahepatic cholestasis of pregnancy: A disorder of increased fetal risks. Part I. Maternal condition

Abstract

The aim of this review was to present the latest developments regarding maternal condition in cases of intrahepatic cholestasis of pregnancy. The changing clinical picture and altered hormonal milieu were related to the underlying cellular and molecular pathomechanisms. Intrahepatic cholestasis of pregnancy may be considered as an obstetric endocrinopathy. The relatively mild course of maternal disease masks the multisystemic nature of the disorder.