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Vol 78, No 5 (2007)
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Present conceptions of etiopathogenesis of polycystic ovary syndrome

Dariusz Radomski, Aleksandra Orzechowska, Ewa Barcz
Ginekol Pol 2007;78(5).

open access

Vol 78, No 5 (2007)
ARTICLES

Abstract

Polycystic ovary syndrome is one of the most common endocrinopathies, occurring in women in reproductive ages. Despite a long history of studies on PCOS, its etiology is still unknown and the very definition remains controversial. This paper presents the most modern concepts which explain the pathophysiology of PCOS, concentrating on a gonadotropic-ovarian and an insulin-dependent model, the roles of a inflammatory state, an endothelium injury and an oxidative stress in PCOS development, as well as postulated genetic mechanisms. The hypo-thetical model of PCOS etiopathogenesis is proposed on the base of the discussed partial con-cepts.

Abstract

Polycystic ovary syndrome is one of the most common endocrinopathies, occurring in women in reproductive ages. Despite a long history of studies on PCOS, its etiology is still unknown and the very definition remains controversial. This paper presents the most modern concepts which explain the pathophysiology of PCOS, concentrating on a gonadotropic-ovarian and an insulin-dependent model, the roles of a inflammatory state, an endothelium injury and an oxidative stress in PCOS development, as well as postulated genetic mechanisms. The hypo-thetical model of PCOS etiopathogenesis is proposed on the base of the discussed partial con-cepts.

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Keywords

polycystic ovary syndrome, ovary - etiopathogenesis, hyperandrogenism

About this article
Title

Present conceptions of etiopathogenesis of polycystic ovary syndrome

Journal

Ginekologia Polska

Issue

Vol 78, No 5 (2007)

Page views

2003

Article views/downloads

1870

Bibliographic record

Ginekol Pol 2007;78(5).

Keywords

polycystic ovary syndrome
ovary - etiopathogenesis
hyperandrogenism

Authors

Dariusz Radomski
Aleksandra Orzechowska
Ewa Barcz

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