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Vol 78, No 5 (2007)
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Evaluation of pregnancy-associated plasma protein A (PAPP-A) and free beta subunit of human chorionic gonadotropin (beta hCG) levels and sonographic assesement of fetal nuchal translucency (NT) in singleton pregnancies between 11 and 14 weeks of gestation – Polish multi-centre research.

Artur Czekierdowski, Piotr Hincz, Wojciech Cnota, Bartosz Czuba, Dariusz Borowski, Joanna Gajewska, Renata Jaczyńska, Alicja Ceran, Agata Włoch, Dorota Wyrwas, Mirosław Wiełgoś, Iwona Szymusik, Krzysztof Szaflik, Krzysztof Sodowski
Ginekol Pol 2007;78(5).

open access

Vol 78, No 5 (2007)
ARTICLES

Abstract

Evaluation of pregnancy-associated plasma protein A (PAPP-A) and free beta subunit of human chorionic gonadotropin (beta hCG) levels and sonographic assesement of fetal nuchal translucency (NT) in singleton pregnancies between 11 and 14 weeks of gestation – Poland’s multi-centers research. Objectives: Pregnancy-associated plasma protein A has been reported to be low in Down syndrome affected pregnancies during the first trimester of pregnancy. Enlarged nuchal translucency (NT) is observed in about 80% of fetuses affected with chromosomal abnormalities and congenital heart defects (CHD). Material and Methods: The aim of this study were to determine value and the medians of free beta-human chorionic gonadotropin (beta-hCG) and pregnancy associated plasma protein-A (PAPP-A) and nuchal translucency thickness in the first trimester in a prospective study of a non-selected Polish population. Results: All examinations have been performed according to the Fetal Medicine Foundation (FMF) rules. We have included 800 women between 11 weeks 0 days and 13 weeks 6 days gestation into a biochemical examination. Women booked into the clinic were offered screening, using a combination of maternal serum free beta-hCG and pregnancy-associated plasma protein-A (PAPP-A) and fetal nuchal translucency thickness. The maternal serum were measured using the Kryptor analyzer (Brahms Diagnostica). All pregnant women have been divided into 2 groups – younger than (first group) and older than (second group) 35 years of age. Conclusions: Nomogrames for free beta-hCG and PAPP-A levels in physiological pregnancy between 11+0 and 13+6 weeks were determined in the examined population. A positive correlation between PAPP-A and CRL levels, as well as a weak negative correlation between free beta-hCG and CRL, were demonstrated.

Abstract

Evaluation of pregnancy-associated plasma protein A (PAPP-A) and free beta subunit of human chorionic gonadotropin (beta hCG) levels and sonographic assesement of fetal nuchal translucency (NT) in singleton pregnancies between 11 and 14 weeks of gestation – Poland’s multi-centers research. Objectives: Pregnancy-associated plasma protein A has been reported to be low in Down syndrome affected pregnancies during the first trimester of pregnancy. Enlarged nuchal translucency (NT) is observed in about 80% of fetuses affected with chromosomal abnormalities and congenital heart defects (CHD). Material and Methods: The aim of this study were to determine value and the medians of free beta-human chorionic gonadotropin (beta-hCG) and pregnancy associated plasma protein-A (PAPP-A) and nuchal translucency thickness in the first trimester in a prospective study of a non-selected Polish population. Results: All examinations have been performed according to the Fetal Medicine Foundation (FMF) rules. We have included 800 women between 11 weeks 0 days and 13 weeks 6 days gestation into a biochemical examination. Women booked into the clinic were offered screening, using a combination of maternal serum free beta-hCG and pregnancy-associated plasma protein-A (PAPP-A) and fetal nuchal translucency thickness. The maternal serum were measured using the Kryptor analyzer (Brahms Diagnostica). All pregnant women have been divided into 2 groups – younger than (first group) and older than (second group) 35 years of age. Conclusions: Nomogrames for free beta-hCG and PAPP-A levels in physiological pregnancy between 11+0 and 13+6 weeks were determined in the examined population. A positive correlation between PAPP-A and CRL levels, as well as a weak negative correlation between free beta-hCG and CRL, were demonstrated.

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Keywords

pregnancy trimester first, prenatal diagnosis, chorionic gonadotropin beta - subunit, Chorionic Gonadotropin - blood

About this article
Title

Evaluation of pregnancy-associated plasma protein A (PAPP-A) and free beta subunit of human chorionic gonadotropin (beta hCG) levels and sonographic assesement of fetal nuchal translucency (NT) in singleton pregnancies between 11 and 14 weeks of gestation – Polish multi-centre research.

Journal

Ginekologia Polska

Issue

Vol 78, No 5 (2007)

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1114

Article views/downloads

29747

Bibliographic record

Ginekol Pol 2007;78(5).

Keywords

pregnancy trimester first
prenatal diagnosis
chorionic gonadotropin beta - subunit
Chorionic Gonadotropin - blood

Authors

Artur Czekierdowski
Piotr Hincz
Wojciech Cnota
Bartosz Czuba
Dariusz Borowski
Joanna Gajewska
Renata Jaczyńska
Alicja Ceran
Agata Włoch
Dorota Wyrwas
Mirosław Wiełgoś
Iwona Szymusik
Krzysztof Szaflik
Krzysztof Sodowski

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