Intrahepatic cholestasis of pregnancy: A disorder with increased fetal risks. Part II: Fetal condition and medical management

Marcin Jóźwik; Maciej Jóźwik; Janusz Bartnicki; Michał Jóźwik

Vol 78, No 5 (2007)

ARTICLES

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Intrahepatic cholestasis of pregnancy: A disorder with increased fetal risks. Part II: Fetal condition and medical management

Marcin Jóźwik, Maciej Jóźwik, Janusz Bartnicki, Michał Jóźwik

Ginekol Pol 2007;78(5).

Vol 78, No 5 (2007)

ARTICLES

Abstract

The aim of this review was to present recent information about the fetal condition in cases of intrahepatic cholestasis of pregnancy. A relatively mild course of maternal disease does not predict fetal well-being accurately. Increased risk of sudden intrauterine death was emphasized, implicating the need for more stringent obstetric monitoring of fetal condition in this disorder. A pathogenetic mechanism leading to sudden deterioration of fetal wellbeing was proposed and discussed. Current recommendations regarding medical management of intrahepatic cholestasis of pregnancy were also presented.