Objectives: The risk of fetal loss after amniocentesis is 0,2-1%. The aim of the study was to compare the course of pregnancy and delivery and the state of the newborn in patients after genetic amniocentesis and in the control group. Material and methods: 783 patients who underwent amniocentesis at the Department of Obstetrics of Medical University of Gdansk in 1996-2003 and 221 women who did not undergo amniocentesis. Results: Fetal loss occurred in 8 pregnancies (3,8%) after amniocentesis and in 12 (5,4%) p=0,37 in the control group. There was no significant statistical difference between the amniocentesis group and the control group comparing complications during pregnancy such as gestational diabetes mellitus, pregnancy induced hypertension, urinary tract infections. Cesarean section was more often performed in the amniocentesis group than in the control group, statistical difference p=0,003. Most often (28,09%) there was an elective cesarean section because of advanced maternal age without any obstetrician cause. The frequency of pneumonia, respiratory infections and congenital malformations in the first weeks of life was more frequent in the amniocetesis group. Conclusions: Invasive prenatal diagnosis has no influence of the frequency of complications during pregnancy and delivery.