Vol 78, No 8 (2007)
ARTICLES
Xenobiotics influence on estrogen activity
Anna Długosz, Anna Stokłosa, Agnieszka Kłodnicka
Vol 78, No 8 (2007)
ARTICLES
Abstract
Many chemical compounds which imitate estrogens effect are present in the environment. There are natural substances (fitoestrogens), as well as synthetic (xenoestrogens, metaloestrogens) ones. A lot of xenobiotics are inductors or inhibitors of enzymes, also those enzymes which take part in estrogens metabolism. However, little is still known about the influence of xenobiotics on estrogens activity, there can be no question of the importance of the problem. One of them are the diminished effects of endogenous estrogens in women smokers, also weakness or lack of oral hormonal replacement therapy (HRT) effect among women smokers, as well as the influence of estrogens on dioxins toxicity. The issue of estrogen compounds presence in cosmetics deserves special attention. It is essential for us to remember, that estrogens are compounds with high biological activity. Thus, hormonal balance disturbance can have serious health consequences, including tumors. In this research we have attempted to present a review of studies which concern exogenous factors influence on estrogens activity and have summarized current state of knowledge.
Abstract
Many chemical compounds which imitate estrogens effect are present in the environment. There are natural substances (fitoestrogens), as well as synthetic (xenoestrogens, metaloestrogens) ones. A lot of xenobiotics are inductors or inhibitors of enzymes, also those enzymes which take part in estrogens metabolism. However, little is still known about the influence of xenobiotics on estrogens activity, there can be no question of the importance of the problem. One of them are the diminished effects of endogenous estrogens in women smokers, also weakness or lack of oral hormonal replacement therapy (HRT) effect among women smokers, as well as the influence of estrogens on dioxins toxicity. The issue of estrogen compounds presence in cosmetics deserves special attention. It is essential for us to remember, that estrogens are compounds with high biological activity. Thus, hormonal balance disturbance can have serious health consequences, including tumors. In this research we have attempted to present a review of studies which concern exogenous factors influence on estrogens activity and have summarized current state of knowledge.
Keywords
Hormone Replacement Therapy - methods, estradiol - analogs and derivatives, Xenoestrogens
Title
Xenobiotics influence on estrogen activity
Journal
Ginekologia Polska
Issue
Vol 78, No 8 (2007)
Page views
655
Article views/downloads
1262
Bibliographic record
Ginekol Pol 2007;78(8).
Keywords
Hormone Replacement Therapy - methods
estradiol - analogs and derivatives
Xenoestrogens
Authors
Anna Długosz
Anna Stokłosa
Agnieszka Kłodnicka
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