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Vol 78, No 9 (2007)
ARTICLES
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Mechanism of the cancerogenesis in cervix paraepidermal epithelium cells with chronic infection of oncogenic types of human papiloma virus

Witold Kędzia, Anna Goździcka-Józefiak
Ginekol Pol 2007;78(9).

open access

Vol 78, No 9 (2007)
ARTICLES

Abstract

The human papillomavirus family is composed of a large number of different and variably related types, each of which is associated with a characteristic set of epithelial lesions. Each of the many identified types of human papillomavirus have shown considerable specificity of different anatomical sites and different characteristic lesions. HPV 6 and 11 are frequently associated with benign condylomas, while HPV 16 and 18 are associated with malignant progression and cervical cancer. The genome of papillomaviruses is composed of a circular double stranded DNA. Various open reading frames (ORFs) are located on only one DNA strand. The coding strand contains from 8 to 10 translational ORFs. Among them, only 6 to 8 were designated as early and 2 as late. The role of HPVs 16 and 18 in uterine cervix carcinoma has been well-documented, but their contriobution to carcinogenesis of other neoplasias is still questionable.

Abstract

The human papillomavirus family is composed of a large number of different and variably related types, each of which is associated with a characteristic set of epithelial lesions. Each of the many identified types of human papillomavirus have shown considerable specificity of different anatomical sites and different characteristic lesions. HPV 6 and 11 are frequently associated with benign condylomas, while HPV 16 and 18 are associated with malignant progression and cervical cancer. The genome of papillomaviruses is composed of a circular double stranded DNA. Various open reading frames (ORFs) are located on only one DNA strand. The coding strand contains from 8 to 10 translational ORFs. Among them, only 6 to 8 were designated as early and 2 as late. The role of HPVs 16 and 18 in uterine cervix carcinoma has been well-documented, but their contriobution to carcinogenesis of other neoplasias is still questionable.
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Keywords

Papillomavirus Infections - complications, Uterine Cervical Neoplasms - virology, Cervical Intraepithelial Neoplasia - virology

About this article
Title

Mechanism of the cancerogenesis in cervix paraepidermal epithelium cells with chronic infection of oncogenic types of human papiloma virus

Journal

Ginekologia Polska

Issue

Vol 78, No 9 (2007)

Bibliographic record

Ginekol Pol 2007;78(9).

Keywords

Papillomavirus Infections - complications
Uterine Cervical Neoplasms - virology
Cervical Intraepithelial Neoplasia - virology

Authors

Witold Kędzia
Anna Goździcka-Józefiak

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