Pregnancy in a patient with seminal hypersensitivity

Abstract

We report a case of a 32-year-old woman with seminal fluid allergy and secondary infertility. She was unable to have unprotected intercourses due to hypersensitivity to the sperm of her spouse. The symptoms started after the delivery of her first child. She was referred to our division for desensitization by means of the intravaginal rush method. The patient was hospitalized for monitoring, and an intravenous line was placed. The first attempt of desensitization was unsuccessful, because of her general hypersensitivity reaction. After the second intravaginal graded challenges, with the use of whole seminal plasma, none of the allergic symptoms appeared. She conceived in a natural way within a month after the treatment. Intravaginal desensitization is an effective and convenient approach for patients with postcoital hypersensitivity reaction who wish to get pregnancy.