Vol 78, No 11 (2007)

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Heart defects and other anomalies in fetuses conceived by assisted reproduction techniques

Patrycja Budziszewska, Agata Włoch, Wioletta Rozmus-Warcholińska, Bartosz Czuba, Dorota Kuka-Panasiuk, Aleksander Ilski, Marcin Sodowski, Wojciech Cnota, Maciej Ziomek, Krzysztof Grettka, Mariusz Kiecka, Krzysztof Sodowski
Ginekol Pol 2007;78(11).


Aim: The aim of the work was to evaluate the frequency of occurrence of structural, chromosome defects and developmental disorders in fetuses conceived with the help of different assisted reproduction techniques. Material and methods: The research group consisted of 30 patients, aged from 25 to 37, subjected to various techniques of assisted reproduction from 2003 to 2006, who reported for consultation in the referral centre. 13 (43%) of the patients underwent the IVF procedure, 12 (40%) the ICSI procedure, 5 patients underwent interuterine insemination. Ultrasonographic examination with the evaluation of the fetal heart was conducted on average in the 22nd week of gestation. Results: Multiple pregnancies constituted 14 (47%) of the examined pregnancies. In total, fetal anomalies were diagnosed in 3 fetuses (6%). Cardiovascular anomalies occurred in 2 fetuses (atrioventricular septal defect – AVSD and ventricular septal defect – VSD), each with diagnosed trisomy of chromosome pairs 21 and 18 respectively. In one case an anomaly within the urinary system was diagnosed. Conclusions: Multiple pregnancies constituted nearly half of the researched group. Structural defects were diagnosed in 3 (6%) fetuses, which slightly exceeds population risk. A higher anomaly percentage occurred in fetuses from twin pregnancies and in the group after ICSI. In the study the risk is related to the selected group of patient undergoing fetal echocardiography exam. To estimate the risk in the ART group precisely, all pregnancies conceived with implementation of ART should be examined. Multi-centre studies are our future goal.

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