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Vol 78, No 12 (2007)
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Pathogenesis and genetics of neural tube defects

Jan Wilczyński, Tomasz Ferenc, Monika Witczak
Ginekol Pol 2007;78(12).

open access

Vol 78, No 12 (2007)
ARTICLES

Abstract

Abstract After congenital heart defects neural tube defects (NTDs) is the second most prevalent congenital malformation among birth defects. The average rate of isolated NTDs is 1.4-2.0 per 1000 live births worldwide. The etiology of isolated (nonsyndromic) NTDs is believed to be the result of a combination of genetic predisposition and environmental factors. Over 80 genes believed to be engaged in the neurulations have been identified during the investigation and research of the mouse models. Despite exhaustive research efforts, now spanning several decades, little is known about the actual genetic mechanisms governing the primary events involved in neural tube closure (NTC).

Abstract

Abstract After congenital heart defects neural tube defects (NTDs) is the second most prevalent congenital malformation among birth defects. The average rate of isolated NTDs is 1.4-2.0 per 1000 live births worldwide. The etiology of isolated (nonsyndromic) NTDs is believed to be the result of a combination of genetic predisposition and environmental factors. Over 80 genes believed to be engaged in the neurulations have been identified during the investigation and research of the mouse models. Despite exhaustive research efforts, now spanning several decades, little is known about the actual genetic mechanisms governing the primary events involved in neural tube closure (NTC).

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Keywords

Neural Tube Defects, pathogenesis, genetics

About this article
Title

Pathogenesis and genetics of neural tube defects

Journal

Ginekologia Polska

Issue

Vol 78, No 12 (2007)

Page views

528

Article views/downloads

3383

Bibliographic record

Ginekol Pol 2007;78(12).

Keywords

Neural Tube Defects
pathogenesis
genetics

Authors

Jan Wilczyński
Tomasz Ferenc
Monika Witczak

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