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Vol 78, No 12 (2007)
ARTICLES
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Markers of oxidative stress in pregnancies complicated by pregnancy induced hypertension and intrahepatic cholestasis

Grzegorz Krasomski, Przemysław Oszukowski, Urszula Brocka, Zbigniew Pietrzak, Lidia Biesiada
Ginekol Pol 2007;78(12).

open access

Vol 78, No 12 (2007)
ARTICLES

Abstract

Abstract Objective: The aim of the study was to investigate levels of superoxide dismutase (CuZnSOD-1), catalase (CAT), glutathione peroxidase (GPx) and malonodialdehyde (MDA) in groups of pregnant women with pregnancy induced hypertension (PIH), hypertension recognized before pregnancy (HA) or intrahepatic cholestasis. Material and methods: 33 women with PIH, 6 with HA and 12 with cholestasis were compared with 33 healthy pregnant women. Levels of enzymes were assessed in blood samples. Methods of delivery and obstetric results were presented. Results: SOD and GPx levels did not differ significantly in any of the investigated groups. A tendency for lower mean levels of CAT in the group of PIH women, and a higher level of MDA in the group of women with HA has been noted. The mean CAT level was significantly lower in PIH and HA patients delivered instantaneously due to the risk of eclampsia. All mean levels of enzymes in the group of women with cholestasis were similar to the ones in the group of healthy women. Patients with PIH and HA gave birth more often by cesarean section, but the overall condition of the newborns was satisfactory. Conclusions: There is no substantial evidence that the level of oxidative enzymes in a blood sample can be an indicator of oxidative stress in pregnant women with PIH, HA or cholestasis. Although CAT levels were lower in PIH and HA women who had cesarean section due to the risk of eclampsia, there was no correlation between these enzyme levels and the clinical outcome of patients or the condition of the newborns.

Abstract

Abstract Objective: The aim of the study was to investigate levels of superoxide dismutase (CuZnSOD-1), catalase (CAT), glutathione peroxidase (GPx) and malonodialdehyde (MDA) in groups of pregnant women with pregnancy induced hypertension (PIH), hypertension recognized before pregnancy (HA) or intrahepatic cholestasis. Material and methods: 33 women with PIH, 6 with HA and 12 with cholestasis were compared with 33 healthy pregnant women. Levels of enzymes were assessed in blood samples. Methods of delivery and obstetric results were presented. Results: SOD and GPx levels did not differ significantly in any of the investigated groups. A tendency for lower mean levels of CAT in the group of PIH women, and a higher level of MDA in the group of women with HA has been noted. The mean CAT level was significantly lower in PIH and HA patients delivered instantaneously due to the risk of eclampsia. All mean levels of enzymes in the group of women with cholestasis were similar to the ones in the group of healthy women. Patients with PIH and HA gave birth more often by cesarean section, but the overall condition of the newborns was satisfactory. Conclusions: There is no substantial evidence that the level of oxidative enzymes in a blood sample can be an indicator of oxidative stress in pregnant women with PIH, HA or cholestasis. Although CAT levels were lower in PIH and HA women who had cesarean section due to the risk of eclampsia, there was no correlation between these enzyme levels and the clinical outcome of patients or the condition of the newborns.
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Keywords

oxidative stress, pregnancy induced hypertension, oxygen free radicals

About this article
Title

Markers of oxidative stress in pregnancies complicated by pregnancy induced hypertension and intrahepatic cholestasis

Journal

Ginekologia Polska

Issue

Vol 78, No 12 (2007)

Bibliographic record

Ginekol Pol 2007;78(12).

Keywords

oxidative stress
pregnancy induced hypertension
oxygen free radicals

Authors

Grzegorz Krasomski
Przemysław Oszukowski
Urszula Brocka
Zbigniew Pietrzak
Lidia Biesiada

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