The diagnostic problems in patient with ascites, elevated Ca 125 level and autoantibodies against nuclear antigens and smooth muscle antigens mimicking advanced ovarian carcinoma – case study

Abstract

Abstract The paper describes a case of 26-year-old patient primarily suspected to suffer from the ovarian or peritoneum cancer due to high level of Ca 125 antigen and ascites. During exploratory laparotomy, neoplastic process was excluded, which was confirmed by histopathological examination. Further diagnostic tests were performed. The patient was not infected with hepatitic B or C virus, and there was no biochemical evidence of liver disease. Detailed, wide biochemical and immunological investigations detected antinuclear and anti smooth muscle autoantibodies in the blood serum. Afterwards, the patient was admitted to the Department of Gastroenterology and autoimmune chronic hepatitis was confirmed.