Rho kinase – a new target for pharmacological treatment of an overactive bladder

Tomasz Rechberger; Paweł Skorupski; Aneta Adamiak; Andrzej Wróbel

Vol 79, No 5 (2008)

ARTICLES

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Rho kinase – a new target for pharmacological treatment of an overactive bladder

Tomasz Rechberger, Paweł Skorupski, Aneta Adamiak, Andrzej Wróbel

Ginekol Pol 2008;79(5).

Vol 79, No 5 (2008)

ARTICLES

Abstract

Abstract Rho kinase plays a key role in the regulation of smooth muscles contraction, including those of the urinary bladder detrusor. Rho kinase pathway modulates the level of phosphorylation of the myosin light chain, mainly through the inhibition of myosin phosphatase. Recent experimental data indicate that its role might be exacerbated in local and systemic pathological conditions which affect the bladder. It seems that Rho kinase inhibitors, such as Y27632, may turn out to be an effective group of drugs in pharmacotheraphy of an overactive bladder (OAB), which will influence the storage phase of the micturition cycle, without interfering with the physiological voiding.