Vol 79, No 5 (2008)
ARTICLES
“Hand-foot” syndrome – after liposomal pegylated doxorubicin in patients with the ovarian cancer recurrence (own experiences)
Beata Kaleta, Elżbieta Nowara, Izolda Morchen-Domin
Vol 79, No 5 (2008)
ARTICLES
Abstract
Abstract Aim: To present our own experience with pegylated liposomal doxorubicin applied in ovarian cancer patients. Material and methods: The group of 32 patients with ovarian cancer was treated with pegylated liposomal doxorubicin (LPD) in Klinika Onkologii Klinicznej Centrum Onkologii Branch Gliwice between the years 2004 and 2007. Median age was 47 years. The histoclinical variables potentially influencing the occurrence of the hand-foot syndrome were analyzed. Results: Hand-foot syndrome has been observed in 11 patients (34,4%) treated with the LPD. The lesions have been present on the skin of hands, feet, elbow and knee joints and armpits. In the analyzed group of patients, the risk of the hand-foot syndrome occurrence increased, however non-significantly, with the increase of number of cycles including LPD (p=0,069) and the number of previous lines of chemotherapy (p=0,067). Other analyzed factors had no negative influence on the hand-foot syndrome occurrence. Conclusions: It is important to inform the patients about the risk of the hand-foot syndrome occurrence and its management. Early diagnosis allows to prevent the worsening of the hand-foot syndrome and makes it possible to continue the chemotherapy without the necessity of dose reduction and breaking from the therapy.
Abstract
Abstract Aim: To present our own experience with pegylated liposomal doxorubicin applied in ovarian cancer patients. Material and methods: The group of 32 patients with ovarian cancer was treated with pegylated liposomal doxorubicin (LPD) in Klinika Onkologii Klinicznej Centrum Onkologii Branch Gliwice between the years 2004 and 2007. Median age was 47 years. The histoclinical variables potentially influencing the occurrence of the hand-foot syndrome were analyzed. Results: Hand-foot syndrome has been observed in 11 patients (34,4%) treated with the LPD. The lesions have been present on the skin of hands, feet, elbow and knee joints and armpits. In the analyzed group of patients, the risk of the hand-foot syndrome occurrence increased, however non-significantly, with the increase of number of cycles including LPD (p=0,069) and the number of previous lines of chemotherapy (p=0,067). Other analyzed factors had no negative influence on the hand-foot syndrome occurrence. Conclusions: It is important to inform the patients about the risk of the hand-foot syndrome occurrence and its management. Early diagnosis allows to prevent the worsening of the hand-foot syndrome and makes it possible to continue the chemotherapy without the necessity of dose reduction and breaking from the therapy.
Keywords
hand-fetal syndrom, liposomal pegylated doxorubicin, ovary cancer
Title
“Hand-foot” syndrome – after liposomal pegylated doxorubicin in patients with the ovarian cancer recurrence (own experiences)
Journal
Ginekologia Polska
Issue
Vol 79, No 5 (2008)
Page views
1138
Article views/downloads
589
Bibliographic record
Ginekol Pol 2008;79(5).
Keywords
hand-fetal syndrom
liposomal pegylated doxorubicin
ovary cancer
Authors
Beata Kaleta
Elżbieta Nowara
Izolda Morchen-Domin