open access

Vol 79, No 9 (2008)
ARTICLES
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Inherited thrombophilia in women with recurrent miscarriages and pregnancy loss in anamnesis – own experience

Agnieszka Kaluba-Skotarczak, Piotr Puacz, Krzysztof Drews, Agnieszka Seremak-mrozikiewicz
Ginekol Pol 2008;79(9).

open access

Vol 79, No 9 (2008)
ARTICLES

Abstract

Summary Single nucleotide polymorphisms of the genes coding for coagulation factors are the cause of congenital thrombophilia which might lead to recurrent miscarriages and fetal loss in advanced pregnancy. The most frequent reasons of thrombophilia are the following: factor V Leiden (1691G>A), mutation 20210G>A of prothrombin gene, and 677C>T of 5,10-methylenetetrahydrofoliate reductase gene. The following article briefly summarizes the administration of antithrombotic prophylaxis (low-molecular weight heparin, acetylsalicylic acid) which seems to be an effective course of action to prevent complications in next pregnancies. What is more, adverse events after long-term usage of low-molecular weight heparin and acetylsalicylic acid in prophylactic doses have not been observed. Due to lack of complete, randomized investigation about the inclusion of antithrombotic prophylaxis in this group of pregnant women, common scheme of administration and optimal dosage is yet to be established.

Abstract

Summary Single nucleotide polymorphisms of the genes coding for coagulation factors are the cause of congenital thrombophilia which might lead to recurrent miscarriages and fetal loss in advanced pregnancy. The most frequent reasons of thrombophilia are the following: factor V Leiden (1691G>A), mutation 20210G>A of prothrombin gene, and 677C>T of 5,10-methylenetetrahydrofoliate reductase gene. The following article briefly summarizes the administration of antithrombotic prophylaxis (low-molecular weight heparin, acetylsalicylic acid) which seems to be an effective course of action to prevent complications in next pregnancies. What is more, adverse events after long-term usage of low-molecular weight heparin and acetylsalicylic acid in prophylactic doses have not been observed. Due to lack of complete, randomized investigation about the inclusion of antithrombotic prophylaxis in this group of pregnant women, common scheme of administration and optimal dosage is yet to be established.
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Keywords

antitrombotic prophylaxis, congenital thrombophilia, pregnancy

About this article
Title

Inherited thrombophilia in women with recurrent miscarriages and pregnancy loss in anamnesis – own experience

Journal

Ginekologia Polska

Issue

Vol 79, No 9 (2008)

Bibliographic record

Ginekol Pol 2008;79(9).

Keywords

antitrombotic prophylaxis
congenital thrombophilia
pregnancy

Authors

Agnieszka Kaluba-Skotarczak
Piotr Puacz
Krzysztof Drews
Agnieszka Seremak-mrozikiewicz

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