open access

Vol 79, No 11 (2008)
ARTICLES
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Xenoestrogens: endocrine disrupting compounds

Marek Murias, Milena Woźniak
Ginekol Pol 2008;79(11).

open access

Vol 79, No 11 (2008)
ARTICLES

Abstract

Summary In recent years much attention has been paid to the issues of chemicals that disrupt the normal function of endocrine system, namely xenoestrogens. These chemicals can mimic the activity of endogenous estrogens, antagonize their interaction with estrogen receptors or disrupt the synthesis, metabolism and functions of endogenous female hormones. Due to the fact that they act thanks to many different mechanisms, it is very difficult to estimate their estrogenic activity by means of a simple tests. The important issue remains the fact that xenoestrogens may have a positive or negative influence on the function of the endocrine system. It seems to be very important that there are many sources of xenoestrogens, that is not only vegetables and fruit (phytoestrogens), but also metals (Co, Cu, Ni, Cr, Pb), dental appliances (alkilphenols), food containers or blood containers (PVC – polyvinyl chloride, DEHP – di-(2-ethylhexyl) phthalate), cosmetics (parabens) and pesticides (DDT - dichlor-diphenyl-trichlorethylane, endosulfane).

Abstract

Summary In recent years much attention has been paid to the issues of chemicals that disrupt the normal function of endocrine system, namely xenoestrogens. These chemicals can mimic the activity of endogenous estrogens, antagonize their interaction with estrogen receptors or disrupt the synthesis, metabolism and functions of endogenous female hormones. Due to the fact that they act thanks to many different mechanisms, it is very difficult to estimate their estrogenic activity by means of a simple tests. The important issue remains the fact that xenoestrogens may have a positive or negative influence on the function of the endocrine system. It seems to be very important that there are many sources of xenoestrogens, that is not only vegetables and fruit (phytoestrogens), but also metals (Co, Cu, Ni, Cr, Pb), dental appliances (alkilphenols), food containers or blood containers (PVC – polyvinyl chloride, DEHP – di-(2-ethylhexyl) phthalate), cosmetics (parabens) and pesticides (DDT - dichlor-diphenyl-trichlorethylane, endosulfane).
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Keywords

Endocrine System, mechanism of action, sources of xenoestrogens, Xenoestrogens

About this article
Title

Xenoestrogens: endocrine disrupting compounds

Journal

Ginekologia Polska

Issue

Vol 79, No 11 (2008)

Bibliographic record

Ginekol Pol 2008;79(11).

Keywords

Endocrine System
mechanism of action
sources of xenoestrogens
Xenoestrogens

Authors

Marek Murias
Milena Woźniak

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