Phalanges necrosis - a rare manifestation of “hand-foot” syndrome induced by gemcitabine used in the second – line therapy for progressive ovarian cancer. A case report

Abstract

Summary “Hand-foot” syndrome is a well-documented, dermatologic reaction after several chemotherapeutic agents with wild spectrum of symptoms. To the best of our knowledge, palmar-plantar erythrodysesthesia syndrome – presented as irreversible cytotoxic side effect induced by gemcitabine alone – has not been reported so far. We present a case of a patient with a history of peripheral sensory neuropathy who developed a painless finger necrosis caused by gemcitabine used in the second-line therapy for progressive ovary cancer.