Vol 80, No 6 (2009)
ARTICLES
Lack of varied endometrial expression of proprotein convertase 6 in infertile women with minimal grade endometriosis and idiopathic infertility
Jana M. Skrzypczak, Przemysław Wirstlein, Mateusz Mikołajczyk
Vol 80, No 6 (2009)
ARTICLES
Abstract
Abstract Objective: Proprotein convertase 6(PC6) is known to be the key enzyme involved in the transformation of many hormones, cytokines and their receptors into their active forms. Experimental in vitro studies have also proven that lack of PC6 in the endometrium prevents decidualisation. Therefore in our study we have aimed at determining whether infertility in some patients might be attributable to decreased expression of PC6. Material and methods: With the use of RealTime PCR we have studied the expression level of PC6 in receptive phase endometria from 36 idiopathic infertile patients, 26 infertile patients with minimal grade endometriosis and compared those results with fertile, age-matched controls. The endometria were collected 7-9 days after ovulation. Results: There were no statistically significant differences regarding the expression of PC6 in endometria from patients with idiopathic infertility, infertile patients with endometriosis and controls. Conclusions: Since there is no detectable difference in PC6 expression, the decreased expression of PC6 is unlikely to cause infertility.
Abstract
Abstract Objective: Proprotein convertase 6(PC6) is known to be the key enzyme involved in the transformation of many hormones, cytokines and their receptors into their active forms. Experimental in vitro studies have also proven that lack of PC6 in the endometrium prevents decidualisation. Therefore in our study we have aimed at determining whether infertility in some patients might be attributable to decreased expression of PC6. Material and methods: With the use of RealTime PCR we have studied the expression level of PC6 in receptive phase endometria from 36 idiopathic infertile patients, 26 infertile patients with minimal grade endometriosis and compared those results with fertile, age-matched controls. The endometria were collected 7-9 days after ovulation. Results: There were no statistically significant differences regarding the expression of PC6 in endometria from patients with idiopathic infertility, infertile patients with endometriosis and controls. Conclusions: Since there is no detectable difference in PC6 expression, the decreased expression of PC6 is unlikely to cause infertility.
Keywords
infertility, endometriosis, proprotein convertase
Title
Lack of varied endometrial expression of proprotein convertase 6 in infertile women with minimal grade endometriosis and idiopathic infertility
Journal
Ginekologia Polska
Issue
Vol 80, No 6 (2009)
Page views
511
Article views/downloads
707
Bibliographic record
Ginekol Pol 2009;80(6).
Keywords
infertility
endometriosis
proprotein convertase
Authors
Jana M. Skrzypczak
Przemysław Wirstlein
Mateusz Mikołajczyk
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