open access

Vol 80, No 7 (2009)
ARTICLES
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Preinvasive vulvar and cervical cancer in a 32-year-old woman, DNA HPV 16 positive with mtDNA mutation – case study

Helena Kędzia, Bogna Guglas, Dominik Pruski, Agata Józefiak, Alicja Wadowicka, Blanka Malkowska-Walczak, Witold Kędzia, Marek Spaczyński
Ginekol Pol 2009;80(7).

open access

Vol 80, No 7 (2009)
ARTICLES

Abstract

Summary Coincidence of preinvasive vulvar and cervical cancer in young women is very rare. Lesions like VIN 3 / preinvasive vulvar cancer and CIN 3 / preinvasive cervical cancer are strictly connected with viral infection and are multilocular. In the presented case the following tests have been performed: HPV DNA test for the presence of 13 oncogenic HPV types, mRNA HPV test for the presence of transcripts for HPV 16, 18, 31, 33, 45 and the analysis of mtDNA D-Loop region. In the examined patient HPV 16 infection, as well as the presence of transcripts for HPV 16 E6/7 were diagnosed. The analysis of mtDNA D-Loop region showed nucleotide lesions like: T>C 16.192, T>C 16.223, T>C 16.292, C>T 16.325, C>T 16.519.

Abstract

Summary Coincidence of preinvasive vulvar and cervical cancer in young women is very rare. Lesions like VIN 3 / preinvasive vulvar cancer and CIN 3 / preinvasive cervical cancer are strictly connected with viral infection and are multilocular. In the presented case the following tests have been performed: HPV DNA test for the presence of 13 oncogenic HPV types, mRNA HPV test for the presence of transcripts for HPV 16, 18, 31, 33, 45 and the analysis of mtDNA D-Loop region. In the examined patient HPV 16 infection, as well as the presence of transcripts for HPV 16 E6/7 were diagnosed. The analysis of mtDNA D-Loop region showed nucleotide lesions like: T>C 16.192, T>C 16.223, T>C 16.292, C>T 16.325, C>T 16.519.
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Keywords

preinvasive vulvar cancer, preinvasive cervical cancer, mtDNA

About this article
Title

Preinvasive vulvar and cervical cancer in a 32-year-old woman, DNA HPV 16 positive with mtDNA mutation – case study

Journal

Ginekologia Polska

Issue

Vol 80, No 7 (2009)

Bibliographic record

Ginekol Pol 2009;80(7).

Keywords

preinvasive vulvar cancer
preinvasive cervical cancer
mtDNA

Authors

Helena Kędzia
Bogna Guglas
Dominik Pruski
Agata Józefiak
Alicja Wadowicka
Blanka Malkowska-Walczak
Witold Kędzia
Marek Spaczyński

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