Abstract Sexual dysfunctions in women is a topic that has only just started to appear in scientific publications. Relatively little is known about the extent of the problem, but some reports suggest that sexual dysfunctions are highly prevalent, affecting 20% to even over 40% of all women. Most authors agree that female sexual dysfunctions are age-related. Epidemiological data confirms that fact and shows that one third of women demonstrate lack of interest in sex and nearly one fourth do not achieve orgasm. Approximately 20% of women report difficulties with vaginal lubrication and for 20% sex is not enjoyable. For many of them such problems influence the relationships with their partner in a negative way and are the reason of personal failures and. It should be emphasized that Hypoactive Sexual Desire Disorder is the most prevalent sexual dysfunction in all female age groups. Until 50 years ago, sexual dysfunction was not regarded as a serious medical problem which is directly responsible for scarce or limited clinical data available on the topic nowadays. The mechanisms underlying Hypoactive Sexual Desire Disorder remain elusive and, as a consequence, in most cases there is still no effective treatment. In recent months, reports have been published suggesting that the situation may change soon. The introduction of new diagnostic tools and data from completed clinical trial phases may prove a real breakthrough in the diagnostics and treatment of the hypoactive sexual desire disorder.