Influence of the selected pyrimidine compounds on the activity of thymidine phosphorylase from normal and tumor endometrial cells

Barbara Jóźwiak; Robert Kubiak; Marcin Dramiński; Monika Smolarek; Elżbieta Miszczak-Zaborska; Jacek Bartkowiak

Vol 80, No 8 (2009)

ARTICLES

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Influence of the selected pyrimidine compounds on the activity of thymidine phosphorylase from normal and tumor endometrial cells

Barbara Jóźwiak, Robert Kubiak, Marcin Dramiński, Monika Smolarek, Elżbieta Miszczak-Zaborska, Jacek Bartkowiak

Ginekol Pol 2009;80(8).

Vol 80, No 8 (2009)

ARTICLES

Abstract

loxymethylthymine was the strongest inhibitor of the TP activity in endometrium, and 1-N-allyloxymethyl-4-hydrokxy-5-nitro-6-oxopyrimidine in endometrial cancer, respectively. The most potent activators of TP in endometrial cancer was 5-bromodeoxyuridine and 1-N-allyloxymethyl-5-nitrouracil, which increased the TP activity about 100%. 5-fluorodeoxyuridine, 5-jododeoxyuridine and 2’-deoxyuridine activated the TP in statistically significant manner too, but stronger in case of endometrial cancer than in normal endometrium. The synthesized 5-bromo-6-acetyloaminouracil strongly inhibited the TP activity of endometrial cells and might be useful in reducing endometrial cancer angiogenesis. On the other hand 5-bromodeoxyuridine and the synthesized 1-N-allyloxymethyl-5-nitrouracil might increase the effect of antitumor therapy with the cytostatics. These conclusions ought to be confirmed by analyzing more tumor cases.