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Vol 80, No 8 (2009)
ARTICLES
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Influence of the selected pyrimidine compounds on the activity of thymidine phosphorylase from normal and tumor endometrial cells

Barbara Jóźwiak, Robert Kubiak, Marcin Dramiński, Monika Smolarek, Elżbieta Miszczak-Zaborska, Jacek Bartkowiak
Ginekol Pol 2009;80(8).

open access

Vol 80, No 8 (2009)
ARTICLES

Abstract

loxymethylthymine was the strongest inhibitor of the TP activity in endometrium, and 1-N-allyloxymethyl-4-hydrokxy-5-nitro-6-oxopyrimidine in endometrial cancer, respectively. The most potent activators of TP in endometrial cancer was 5-bromodeoxyuridine and 1-N-allyloxymethyl-5-nitrouracil, which increased the TP activity about 100%. 5-fluorodeoxyuridine, 5-jododeoxyuridine and 2’-deoxyuridine activated the TP in statistically significant manner too, but stronger in case of endometrial cancer than in normal endometrium. The synthesized 5-bromo-6-acetyloaminouracil strongly inhibited the TP activity of endometrial cells and might be useful in reducing endometrial cancer angiogenesis. On the other hand 5-bromodeoxyuridine and the synthesized 1-N-allyloxymethyl-5-nitrouracil might increase the effect of antitumor therapy with the cytostatics. These conclusions ought to be confirmed by analyzing more tumor cases.

Abstract

loxymethylthymine was the strongest inhibitor of the TP activity in endometrium, and 1-N-allyloxymethyl-4-hydrokxy-5-nitro-6-oxopyrimidine in endometrial cancer, respectively. The most potent activators of TP in endometrial cancer was 5-bromodeoxyuridine and 1-N-allyloxymethyl-5-nitrouracil, which increased the TP activity about 100%. 5-fluorodeoxyuridine, 5-jododeoxyuridine and 2’-deoxyuridine activated the TP in statistically significant manner too, but stronger in case of endometrial cancer than in normal endometrium. The synthesized 5-bromo-6-acetyloaminouracil strongly inhibited the TP activity of endometrial cells and might be useful in reducing endometrial cancer angiogenesis. On the other hand 5-bromodeoxyuridine and the synthesized 1-N-allyloxymethyl-5-nitrouracil might increase the effect of antitumor therapy with the cytostatics. These conclusions ought to be confirmed by analyzing more tumor cases.
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Keywords

Thymidine phosphorylase, Endometrial Neoplasms

About this article
Title

Influence of the selected pyrimidine compounds on the activity of thymidine phosphorylase from normal and tumor endometrial cells

Journal

Ginekologia Polska

Issue

Vol 80, No 8 (2009)

Bibliographic record

Ginekol Pol 2009;80(8).

Keywords

Thymidine phosphorylase
Endometrial Neoplasms

Authors

Barbara Jóźwiak
Robert Kubiak
Marcin Dramiński
Monika Smolarek
Elżbieta Miszczak-Zaborska
Jacek Bartkowiak

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