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Vol 80, No 8 (2009)
ARTICLES
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Umbilical cord plasma endothelin 1 and cyclic guanosine concentrations monophosphate at delivery in pregnancy complicated by diabetes mellitus

Tomasz Miazgowski, Zbigniew Celewicz, Sławomir Świderski
Ginekol Pol 2009;80(8).

open access

Vol 80, No 8 (2009)
ARTICLES

Abstract

Abstract Objectives: The aim of the study was to assess the relationship between maternal and umbilical cord plasma concentrations of endothelin 1 (ET-1) and cyclic guanosine monophosphate (cGMP) in women with diabetes mellitus (DM). Material and methods: The study was performed on 19 neonates of women with pregestational DM, 23 neonates of women with gestational diabetes (GDM), and 18 neonates of healthy, uncomplicated pregnancies. Results: We found that umbilical and maternal ET-1 and cGMP concentrations in pregestational DM or GDM women were not changed in comparison with the controls. In women without DM, positive correlations between maternal (r=0.64; p<0.005) and umbilical cord plasma (r=0.60; p<0.009) ET-1 and cGMP concentrations were found. However, in pregnancies complicated by pregestational DM or GDM such associations were not observed. Conclusions: Umbilical and maternal plasma concentrations of ET-1 and cGMP in pregnant women with pregestational diabetes as well as gestational diabetes were not changed in comparison with the non-diabetic women. In women without DM maternal and umbilical cord plasma ET-1 and cGMP concentrations showed positive correlations. In pregnancies complicated by pregestational DM or GDM maternal and umbilical cord plasma ET-1 and cGMP concentrations were not interdependent.

Abstract

Abstract Objectives: The aim of the study was to assess the relationship between maternal and umbilical cord plasma concentrations of endothelin 1 (ET-1) and cyclic guanosine monophosphate (cGMP) in women with diabetes mellitus (DM). Material and methods: The study was performed on 19 neonates of women with pregestational DM, 23 neonates of women with gestational diabetes (GDM), and 18 neonates of healthy, uncomplicated pregnancies. Results: We found that umbilical and maternal ET-1 and cGMP concentrations in pregestational DM or GDM women were not changed in comparison with the controls. In women without DM, positive correlations between maternal (r=0.64; p<0.005) and umbilical cord plasma (r=0.60; p<0.009) ET-1 and cGMP concentrations were found. However, in pregnancies complicated by pregestational DM or GDM such associations were not observed. Conclusions: Umbilical and maternal plasma concentrations of ET-1 and cGMP in pregnant women with pregestational diabetes as well as gestational diabetes were not changed in comparison with the non-diabetic women. In women without DM maternal and umbilical cord plasma ET-1 and cGMP concentrations showed positive correlations. In pregnancies complicated by pregestational DM or GDM maternal and umbilical cord plasma ET-1 and cGMP concentrations were not interdependent.
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Keywords

endothelin 1, cyclic quanosine monophosphate, Diabetes mellitus, pregnancy

About this article
Title

Umbilical cord plasma endothelin 1 and cyclic guanosine concentrations monophosphate at delivery in pregnancy complicated by diabetes mellitus

Journal

Ginekologia Polska

Issue

Vol 80, No 8 (2009)

Bibliographic record

Ginekol Pol 2009;80(8).

Keywords

endothelin 1
cyclic quanosine monophosphate
Diabetes mellitus
pregnancy

Authors

Tomasz Miazgowski
Zbigniew Celewicz
Sławomir Świderski

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