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Vol 81, No 2 (2010)
ARTICLES
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Tocolytic therapy in threatened preterm labor

Beata Marciniak, Bożena Leszczyńska-Gorzelak, Żaneta Kimber-Trojnar, Jacek Bartosiewicz, Jan Oleszczuk
Ginekol Pol 2010;81(2).

open access

Vol 81, No 2 (2010)
ARTICLES

Abstract

Summary The most important benefit of tocolysis is a 48-hour prolongation of gestational age in order to administer corticosteroids to reduce perinatal mortality and morbidity, as well as, if necessary, to gain time for “in utero” transfer to a tertiary centre with neonatal facilities. The tocolytic agents used in clinical practice can be grouped into six classes, namely: calcium channel blockers, betamimetics, magnesium sulfate, cyclooxygenase inhibitors, oxytocin receptor antagonists and nitric oxide donors. The use of them should be individualized and based on tocolytic effectiveness, safety, gestational age as well as maternal, fetal and neonatal outcomes. Data from clinical trials suggests that nifedipine appears to be the drug of first choice in the management of preterm labor.

Abstract

Summary The most important benefit of tocolysis is a 48-hour prolongation of gestational age in order to administer corticosteroids to reduce perinatal mortality and morbidity, as well as, if necessary, to gain time for “in utero” transfer to a tertiary centre with neonatal facilities. The tocolytic agents used in clinical practice can be grouped into six classes, namely: calcium channel blockers, betamimetics, magnesium sulfate, cyclooxygenase inhibitors, oxytocin receptor antagonists and nitric oxide donors. The use of them should be individualized and based on tocolytic effectiveness, safety, gestational age as well as maternal, fetal and neonatal outcomes. Data from clinical trials suggests that nifedipine appears to be the drug of first choice in the management of preterm labor.
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Keywords

Tocolytic Agents, premature birth, Calcium Channel Blockers

About this article
Title

Tocolytic therapy in threatened preterm labor

Journal

Ginekologia Polska

Issue

Vol 81, No 2 (2010)

Bibliographic record

Ginekol Pol 2010;81(2).

Keywords

Tocolytic Agents
premature birth
Calcium Channel Blockers

Authors

Beata Marciniak
Bożena Leszczyńska-Gorzelak
Żaneta Kimber-Trojnar
Jacek Bartosiewicz
Jan Oleszczuk

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