Abstract Aim: The study aimed at: 1. analysis of the relationship between Doppler flow in the selected maternal and fetal vessels and the risk of adverse perinatal outcome (APO); 2. multivariate logistic regression model for the assessment the risk of APA. Material and methods: The study population covered 216 pregnant women from Lodz and Kalisz between 2003-2006. Results: In univariate logistic regression model PI_UA significantly influenced the risk of APO. That risk was increasing 1.2 times, if the PI_UA value was 1/10th higher than the measured unit. Abnormal cardiotocography (CTG) pattern was related to 12-times higher risk of APO. In cases of abnormal PI_MCA, the risk of APO was 2.5 times higher than when PI_MCA was within the normal range. Abnormal PI_UA was related to 11.5-times higher risk of APO. Similarly, when PIV_DV was abnormal, the risk of APO was 2.3-times higher. Low birth weight (LBW) was connected with the 6-times higher risk of APO. In multivariate logistic regression model, CTG and LBW were the risk factors significantly associated with APA. Abnormal CTG pattern was related to more than 6-times higher increase of the risk of APO, however LBW with nearly 4-times higher risk of APO. Conclusion: Abnormal values of PI in UA and in MCA, abnormal flow in DV, and abnormal CTG pattern, as well as low birth weight, had significant influence on the risk of APO. In multivariate analysis only abnormal CTG and low birth weight were the significant factors of APO.