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Vol 81, No 6 (2010)
ARTICLES
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Tumor necrosis factor in uterine leiomyomas at various stages of tumor growth

Małgorzata Wolańska, Ewelina Taudul, Emilia Bańkowska-Gruszczyn, Maciej Kinalski
Ginekol Pol 2010;81(6).

open access

Vol 81, No 6 (2010)
ARTICLES

Abstract

Summary Objectives: The aim of the study was to evaluate the expression of tumor necrosis factors -α and β (TNF), their receptor and content in human uterine leiomyomas at various stages of tumor growth. Material and Methods: Studies were performed on human myometrium and uterine leiomyomas of various weights (small: less than 10g and large: more than 100g). Presence of both growth factors and their receptor was detected by Western Immunoblotting technique. The content of TNF-α was evaluated by immunoenzymatic method (ELISA). Results: Changes in the expression of tumor necrosis factors and their receptor and difference in content of TNF-α during the tumor growth were found. Conclusions: Myometrium conversion into leiomyoma and an increase in its mass is accompanied by changes in the expression and contents TNF and TNF RI.

Abstract

Summary Objectives: The aim of the study was to evaluate the expression of tumor necrosis factors -α and β (TNF), their receptor and content in human uterine leiomyomas at various stages of tumor growth. Material and Methods: Studies were performed on human myometrium and uterine leiomyomas of various weights (small: less than 10g and large: more than 100g). Presence of both growth factors and their receptor was detected by Western Immunoblotting technique. The content of TNF-α was evaluated by immunoenzymatic method (ELISA). Results: Changes in the expression of tumor necrosis factors and their receptor and difference in content of TNF-α during the tumor growth were found. Conclusions: Myometrium conversion into leiomyoma and an increase in its mass is accompanied by changes in the expression and contents TNF and TNF RI.
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Keywords

TNF, TNF RI, tumor necrosis factor, leiomyoma

About this article
Title

Tumor necrosis factor in uterine leiomyomas at various stages of tumor growth

Journal

Ginekologia Polska

Issue

Vol 81, No 6 (2010)

Bibliographic record

Ginekol Pol 2010;81(6).

Keywords

TNF
TNF RI
tumor necrosis factor
leiomyoma

Authors

Małgorzata Wolańska
Ewelina Taudul
Emilia Bańkowska-Gruszczyn
Maciej Kinalski

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