Błąd cURL: Failed connect to www.viamedica.pl:443; No route to host
Vol 81, No 6 (2010)
ARTICLES

open access

Page views 501
Article views/downloads 2185
Get Citation

Connect on Social Media

Connect on Social Media

Tumor necrosis factor in uterine leiomyomas at various stages of tumor growth

Małgorzata Wolańska, Ewelina Taudul, Emilia Bańkowska-Gruszczyn, Maciej Kinalski
Ginekol Pol 2010;81(6).

Abstract

Summary Objectives: The aim of the study was to evaluate the expression of tumor necrosis factors -α and β (TNF), their receptor and content in human uterine leiomyomas at various stages of tumor growth. Material and Methods: Studies were performed on human myometrium and uterine leiomyomas of various weights (small: less than 10g and large: more than 100g). Presence of both growth factors and their receptor was detected by Western Immunoblotting technique. The content of TNF-α was evaluated by immunoenzymatic method (ELISA). Results: Changes in the expression of tumor necrosis factors and their receptor and difference in content of TNF-α during the tumor growth were found. Conclusions: Myometrium conversion into leiomyoma and an increase in its mass is accompanied by changes in the expression and contents TNF and TNF RI.

Article available in PDF format

View PDF Download PDF file
Błąd cURL: Failed connect to www.viamedica.pl:443; No route to host