open access

Vol 81, No 8 (2010)
ARTICLES
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Statins in the treatment of polycystic ovary syndrome

Beata Banaszewska, Robert Spaczyński, Leszek Pawelczyk
Ginekol Pol 2010;81(8).

open access

Vol 81, No 8 (2010)
ARTICLES

Abstract

Summary Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting 6-9% of women in reproductive age. It is characterized by hyperandrogenism, oligo- or anovulation and infertility. PCOS is associated with important cardiovascular risk factors including: obesity, dyslipidemia , systemic inflammation and endothelial dysfunction. Statins are well-tested medications reducing a broad range of cardiovascular risk factors. The primary mode of action of statins is inhibition of HMG-Co A reductase, a rate-limiting step of cholesterol synthesis. In recent randomized studies in PCOS women, statins have decreased testosterone level, improved menstrual cycle regularity and lipid profile.

Abstract

Summary Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting 6-9% of women in reproductive age. It is characterized by hyperandrogenism, oligo- or anovulation and infertility. PCOS is associated with important cardiovascular risk factors including: obesity, dyslipidemia , systemic inflammation and endothelial dysfunction. Statins are well-tested medications reducing a broad range of cardiovascular risk factors. The primary mode of action of statins is inhibition of HMG-Co A reductase, a rate-limiting step of cholesterol synthesis. In recent randomized studies in PCOS women, statins have decreased testosterone level, improved menstrual cycle regularity and lipid profile.
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Keywords

statins, polycitic ovary syndrome, dyslipidemia

About this article
Title

Statins in the treatment of polycystic ovary syndrome

Journal

Ginekologia Polska

Issue

Vol 81, No 8 (2010)

Bibliographic record

Ginekol Pol 2010;81(8).

Keywords

statins
polycitic ovary syndrome
dyslipidemia

Authors

Beata Banaszewska
Robert Spaczyński
Leszek Pawelczyk

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