Vol 81, No 8 (2010)

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Concentration of selected biochemical parameters in blood of pregnant women infected by HPV 16 and 18

Agata Karowicz-Bilińska, Maria Brzozowska, Dorota Estemberg, Ewa Kuś, Marlena Berner-Trąbska, Urszula Kowalska-Koprek
Ginekol Pol 2010;81(8).


Summary Asymptomatic HPV infection in pregnant women may be connected with changes of pro-inflammatory cytokines and proteolytic enzymes which may condition the persistence of infection during pregnancy. Aim: The main aim of the study was to evaluate the concentration of interleukin-1, TNF-α and α-1 antitrypsin in pregnant women infected by oncogenic types HPV. Materials and method: The study was conducted in 2008-2009 at the Department of Obstetrics and Gynecology, Medical University Lodz, on pregnant women in the third trimester of pregnancy. The study group consisted on 19 pregnant women HPV-16, -18 infected. The control group consisted on 34 pregnant women at the same gestational age, HPV-negative. The concentration of interleukin-1, TNF-α and α-1 antitripsin was estimated in blood. Results: The results of concentration interleukin-1, TNF-α and α-1 antitrypsin were similar in both groups of pregnant women. Conclusions: High risk HPV infection has no influence on the concentration of pro- inflammatory cytokines. In HPV infection during pregnancy the anti proteolytic defense did not decrease.

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