Vol 81, No 9 (2010)

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Expression of survivin, SDF-1 and CXCR4 on tumor cells in ovarian cancer

Ewa Nowak-Markwitz, Bartosz Puła, Marta Szajnik, Piotr Dzięgiel, Aleksandra Piotrowska, Maciej Zabel, Marek Spaczyński
Ginekol Pol 2010;81(9).


Summary Background: epithelial ovarian cancer (EOC) has the highest mortality rate among patients with gynecologic malignancies. Lack of specific and early symptoms and of screening tests causes that most patients are diagnosed in advanced stage of disease. Radical surgery followed by chemotherapy does not bring satisfactory curative effects. Objectives: the urgent need exists to define the optimum biomarker for ovarian cancer to predict patients’ response to curative therapy. Our current study aimed at correlation between the expression of survivin, SDF-1, CXCR-4 on tumor tissue and clinical outcome of patients with ovarian cancer. Results: we showed that survivin expression correlates with histological grading of the tumor. No correlation was found in terms of SDF-1/CXCR-4 expression and clinicopathologic data. Conclusions: further studies covering larger number of patients are needed to determine whether SDF-1 and CXCR-4 might be considered as biomarkers for ovarian cancer.

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