Comparative analysis of abnormal Pap smear and the results of histopathological examination of specimens from the cervix of the Programme in-depth Diagnosis Cervical Cancer conducted at the of Operational Gynecology Department ICZMP in Lodz

Abstract

Abstract Introduction: Cervical Cancer Screening Program has been operational in Poland for over four years. Colposcopy and guided biopsy methods constitute an essential part of population-based screening, enable stating right diagnosis and planning treatment procedures. Aim: The aim of the following study was to analyse the diagnostic acuity of cyto- and histopathological examination. Results: We examined 510 patients with the following result of cytological smear : ASCUS – 265 women (51.96%), LSIL – 167 cases (35.75%), HSIL – 78 women (15.29%). Complete agreement between cytological smear and guided biopsy histopathology was observed among 81.13% cases of ASCUS, in 88.02% of women with LSIL and in 76.92% cases with the diagnosis of HSIL. As with cytology-biopsy comparisons, discordant cases were significantly more frequent in the group with stated HSIL than among patients with the diagnosis of ASCUS or LSIL (p<0.001). Conclusions: 1. High cyto- histopathological accordance (82%) has been obtained, what is comparable with the data in literature. 2. The highest cyto- histopathological compatibility was obtained in the group of patients with LSIL – over 88%, and the lowest in the group of patients with HSIL – less than 77%. 3. Failure to confirm the histopathological diagnosis of cytological HSIL requires further molecular and morphological evaluation.