open access

Vol 82, No 3 (2011)
ARTICLES
Get Citation

Antitumor effects of sulindac in ovarian cell cultures

Anna Jakubowska-Mućka, Jacek Sieńko, Tomasz Świtaj, Jakub Gołąb, Witold Lasek
Ginekol Pol 2011;82(3).

open access

Vol 82, No 3 (2011)
ARTICLES

Abstract

Abstract Objective: The purpose of our study was to assess susceptibility of cells of various ovarian cell lines on different nonsteroidal anti-inflammatory drugs (NSAIDs). Materials and methods: Cytotoxic effect of NSAIDs was tested using MTT colorimetric assay. Results: Amongst 6 NSAIDs tested: sulindac, sulindac sulfide, sulindac sulfone, acetylsalicylic acid, nimesulide, and rofecoxib, viability of ovarian carcinoma cells was compromised most strongly by sulindac and sulindac sulfide and concerned all the cell lines tested: SKOV-3, MDAH 2774, OVCA-1, and OVP-10. Sulindac sulfone and rofecoxib also displayed some cytotoxic effect during prolonged 72-hour incubation. Other NSAIDs tested: nimesulide and acetylsalicylic acid were devoid of cytotoxic effect on ovarian cancer cells. Conclusion: Our results are encourage enough to conduct clinical trials that could allow to draw conclusions regarding potential application of sulindac in the adjuvant treatment of a standard chemotherapy of ovarian cancer.

Abstract

Abstract Objective: The purpose of our study was to assess susceptibility of cells of various ovarian cell lines on different nonsteroidal anti-inflammatory drugs (NSAIDs). Materials and methods: Cytotoxic effect of NSAIDs was tested using MTT colorimetric assay. Results: Amongst 6 NSAIDs tested: sulindac, sulindac sulfide, sulindac sulfone, acetylsalicylic acid, nimesulide, and rofecoxib, viability of ovarian carcinoma cells was compromised most strongly by sulindac and sulindac sulfide and concerned all the cell lines tested: SKOV-3, MDAH 2774, OVCA-1, and OVP-10. Sulindac sulfone and rofecoxib also displayed some cytotoxic effect during prolonged 72-hour incubation. Other NSAIDs tested: nimesulide and acetylsalicylic acid were devoid of cytotoxic effect on ovarian cancer cells. Conclusion: Our results are encourage enough to conduct clinical trials that could allow to draw conclusions regarding potential application of sulindac in the adjuvant treatment of a standard chemotherapy of ovarian cancer.
Get Citation

Keywords

ovarian cancer, Sulindac, anti-inflammatory drugs

About this article
Title

Antitumor effects of sulindac in ovarian cell cultures

Journal

Ginekologia Polska

Issue

Vol 82, No 3 (2011)

Bibliographic record

Ginekol Pol 2011;82(3).

Keywords

ovarian cancer
Sulindac
anti-inflammatory drugs

Authors

Anna Jakubowska-Mućka
Jacek Sieńko
Tomasz Świtaj
Jakub Gołąb
Witold Lasek

Regulations

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk
tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl