Vol 82, No 5 (2011)
ARTICLES
Changes in the concentration of sHLA-I and selected cytokines in pregnancy complicated by antiphospholipid syndrome
Olimpia Sipak-Szmigiel, Magdalena Podolska, Tomasz Płonka, Piotr Włodarski, Elżbieta Ronin-Walknowska
Vol 82, No 5 (2011)
ARTICLES
Abstract
Summary Objectives: To compare the serum concentrations of the selected cytokines from subsequent trimesters of antiphospholipid syndrome complicated pregnancies. Material and Methods: This study included 43 pregnant women (23 patients diagnosed with antiphospholipid syndrome and 20 controls). IL-2R, IL-4, IL-10, INF-γ, TNF-α, and class I sHLA concentrations were analyzed by ELISA in the 1st, 2nd and 3rd trimester. Results: INF-γ levels were below the method detection threshold and therefore were not included in the final analysis. No significant changes in IL-2R, IL-4, IL-10, TNF-α, and class I sHLA concentrations were observed in subsequent trimesters in the group of women with antiphospholipid syndrome. Significant decrease in IL-10 in the 2nd trimester along with significant increase in TNF-α in the 3rd trimester were noted amongst the control subjects. The only significant inter-group difference was observed in the 1st trimester when mean TNF-α level was significantly higher among antiphospholipid syndrome women if compared to controls. Conclusions: The observed lack of significant differences between antiphospholipid syndrome affected and control group pregnancies in their sHLA class I and cytokine concentrations may be related to the fact that the treatment of antiphospholipid syndrome was implemented early and continued throughout all trimesters of the pregnancy.
Abstract
Summary Objectives: To compare the serum concentrations of the selected cytokines from subsequent trimesters of antiphospholipid syndrome complicated pregnancies. Material and Methods: This study included 43 pregnant women (23 patients diagnosed with antiphospholipid syndrome and 20 controls). IL-2R, IL-4, IL-10, INF-γ, TNF-α, and class I sHLA concentrations were analyzed by ELISA in the 1st, 2nd and 3rd trimester. Results: INF-γ levels were below the method detection threshold and therefore were not included in the final analysis. No significant changes in IL-2R, IL-4, IL-10, TNF-α, and class I sHLA concentrations were observed in subsequent trimesters in the group of women with antiphospholipid syndrome. Significant decrease in IL-10 in the 2nd trimester along with significant increase in TNF-α in the 3rd trimester were noted amongst the control subjects. The only significant inter-group difference was observed in the 1st trimester when mean TNF-α level was significantly higher among antiphospholipid syndrome women if compared to controls. Conclusions: The observed lack of significant differences between antiphospholipid syndrome affected and control group pregnancies in their sHLA class I and cytokine concentrations may be related to the fact that the treatment of antiphospholipid syndrome was implemented early and continued throughout all trimesters of the pregnancy.
Keywords
pregnancy, cytokines, antiphosphospholipid syndrome, class I sHLA
Title
Changes in the concentration of sHLA-I and selected cytokines in pregnancy complicated by antiphospholipid syndrome
Journal
Ginekologia Polska
Issue
Vol 82, No 5 (2011)
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500
Article views/downloads
560
Bibliographic record
Ginekol Pol 2011;82(5).
Keywords
pregnancy
cytokines
antiphosphospholipid syndrome
class I sHLA
Authors
Olimpia Sipak-Szmigiel
Magdalena Podolska
Tomasz Płonka
Piotr Włodarski
Elżbieta Ronin-Walknowska
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