open access

Vol 82, No 5 (2011)
ARTICLES
Get Citation

Changes in the concentration of sHLA-I and selected cytokines in pregnancy complicated by antiphospholipid syndrome

Olimpia Sipak-Szmigiel, Magdalena Podolska, Tomasz Płonka, Piotr Włodarski, Elżbieta Ronin-Walknowska
Ginekol Pol 2011;82(5).

open access

Vol 82, No 5 (2011)
ARTICLES

Abstract

Summary Objectives: To compare the serum concentrations of the selected cytokines from subsequent trimesters of antiphospholipid syndrome complicated pregnancies. Material and Methods: This study included 43 pregnant women (23 patients diagnosed with antiphospholipid syndrome and 20 controls). IL-2R, IL-4, IL-10, INF-γ, TNF-α, and class I sHLA concentrations were analyzed by ELISA in the 1st, 2nd and 3rd trimester. Results: INF-γ levels were below the method detection threshold and therefore were not included in the final analysis. No significant changes in IL-2R, IL-4, IL-10, TNF-α, and class I sHLA concentrations were observed in subsequent trimesters in the group of women with antiphospholipid syndrome. Significant decrease in IL-10 in the 2nd trimester along with significant increase in TNF-α in the 3rd trimester were noted amongst the control subjects. The only significant inter-group difference was observed in the 1st trimester when mean TNF-α level was significantly higher among antiphospholipid syndrome women if compared to controls. Conclusions: The observed lack of significant differences between antiphospholipid syndrome affected and control group pregnancies in their sHLA class I and cytokine concentrations may be related to the fact that the treatment of antiphospholipid syndrome was implemented early and continued throughout all trimesters of the pregnancy.

Abstract

Summary Objectives: To compare the serum concentrations of the selected cytokines from subsequent trimesters of antiphospholipid syndrome complicated pregnancies. Material and Methods: This study included 43 pregnant women (23 patients diagnosed with antiphospholipid syndrome and 20 controls). IL-2R, IL-4, IL-10, INF-γ, TNF-α, and class I sHLA concentrations were analyzed by ELISA in the 1st, 2nd and 3rd trimester. Results: INF-γ levels were below the method detection threshold and therefore were not included in the final analysis. No significant changes in IL-2R, IL-4, IL-10, TNF-α, and class I sHLA concentrations were observed in subsequent trimesters in the group of women with antiphospholipid syndrome. Significant decrease in IL-10 in the 2nd trimester along with significant increase in TNF-α in the 3rd trimester were noted amongst the control subjects. The only significant inter-group difference was observed in the 1st trimester when mean TNF-α level was significantly higher among antiphospholipid syndrome women if compared to controls. Conclusions: The observed lack of significant differences between antiphospholipid syndrome affected and control group pregnancies in their sHLA class I and cytokine concentrations may be related to the fact that the treatment of antiphospholipid syndrome was implemented early and continued throughout all trimesters of the pregnancy.
Get Citation

Keywords

pregnancy, cytokines, antiphosphospholipid syndrome, class I sHLA

About this article
Title

Changes in the concentration of sHLA-I and selected cytokines in pregnancy complicated by antiphospholipid syndrome

Journal

Ginekologia Polska

Issue

Vol 82, No 5 (2011)

Bibliographic record

Ginekol Pol 2011;82(5).

Keywords

pregnancy
cytokines
antiphosphospholipid syndrome
class I sHLA

Authors

Olimpia Sipak-Szmigiel
Magdalena Podolska
Tomasz Płonka
Piotr Włodarski
Elżbieta Ronin-Walknowska

Regulations

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk
tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl