open access

Vol 82, No 6 (2011)
ARTICLES
Get Citation

The role of 1691G > A (Leiden) mutation in Factor V gene, 20210G > A in prothrombin gene and 677C > T in MTHFR gene in etiology of early pregnancy loss

Dorota Reszczyńska-Ślęzak, Paweł Karpiński, Łukasz Łaczmański, Ryszard Ślęzak
Ginekol Pol 2011;82(6).

open access

Vol 82, No 6 (2011)
ARTICLES

Abstract

Summary Objectives: The objective of this study was to investigate the prevalence of common hereditary risk factors for thrombophilia (mutations 1691G>A, 20210G>A and 677C>T variant in factor V Leiden (FV), prothrombin (FII) and MTHFR gene, respectively) – in a cohort of women with early pregnancy loss. Material and methods: Frequency of mutations in FV, FII and MTHFR was assessed by PCR-RFLP or minisequencing in a cohort of 313 women with a history of at least two miscarriages and the control group consisting of 200 women without obstetric complications. Results: Compared with controls, neither FV mutation (3.2% vs 3%; p=0.45) nor the MTHFR 677TT variant (8.4% vs 11.1%; p=0.58) was more prevalent in the patients. Mutation in FII gene was more frequent in the patients (3.5% vs 0.5%; p=0.03) when compared with controls, however, the frequency of this mutation in controls was lower than estimated frequency in the population.

Abstract

Summary Objectives: The objective of this study was to investigate the prevalence of common hereditary risk factors for thrombophilia (mutations 1691G>A, 20210G>A and 677C>T variant in factor V Leiden (FV), prothrombin (FII) and MTHFR gene, respectively) – in a cohort of women with early pregnancy loss. Material and methods: Frequency of mutations in FV, FII and MTHFR was assessed by PCR-RFLP or minisequencing in a cohort of 313 women with a history of at least two miscarriages and the control group consisting of 200 women without obstetric complications. Results: Compared with controls, neither FV mutation (3.2% vs 3%; p=0.45) nor the MTHFR 677TT variant (8.4% vs 11.1%; p=0.58) was more prevalent in the patients. Mutation in FII gene was more frequent in the patients (3.5% vs 0.5%; p=0.03) when compared with controls, however, the frequency of this mutation in controls was lower than estimated frequency in the population.
Get Citation

Keywords

MTHFR, spontaneus abrotion, Factor V, Prothrombin, trombophilia

About this article
Title

The role of 1691G>A (Leiden) mutation in Factor V gene, 20210G>A in prothrombin gene and 677C>T in MTHFR gene in etiology of early pregnancy loss

Journal

Ginekologia Polska

Issue

Vol 82, No 6 (2011)

Bibliographic record

Ginekol Pol 2011;82(6).

Keywords

MTHFR
spontaneus abrotion
Factor V
Prothrombin
trombophilia

Authors

Dorota Reszczyńska-Ślęzak
Paweł Karpiński
Łukasz Łaczmański
Ryszard Ślęzak

Regulations

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk
tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl