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Vol 82, No 6 (2011)
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The influence of low-dose oral contraceptive pill on clinical and metabolic parameters in young women with polycystic ovary syndrome

Beata Banaszewska, Robert Z. Spaczyński, Katarzyna Ożegowska, Leszek Pawelczyk
Ginekol Pol 2011;82(6).

open access

Vol 82, No 6 (2011)
ARTICLES

Abstract

Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, oligo/anovulation and is associated with risk factors for cardiovascular diseases, such as insulin resistance and central adiposity. The aim of the study was to evaluation of influence of the oral contraceptive pill on the endocrinologic and metabolic parameters in women with PCOS. Material & methods: Forty nine PCOS women (aged 23,9±3,5 [mean±SD]) without any other diseases were included into the study. Oral contraceptives (0,02mg ethynylestradiol +0,15 mg desogestrel) were administered for 6 months. Hormonal and biochemical analyses were performed with specific assays at the beginning and after 6 month-therapy. BMI, insulin sensitivity index (ISI) and QUICKI were calculated. Statistical analysis was performed using Results: All patients completed 6-month therapy and no severe side effects were reported during the study. A significant reduction in testosterone (T) concentrations was observed (p<0.005). We recorded a significant increase in lipid concentrations. Conclusions: The administration of oral contraceptives in our study group caused decrease in the testosterone level but negative effect on total cholesterol and triglycerides level was observed.

Abstract

Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, oligo/anovulation and is associated with risk factors for cardiovascular diseases, such as insulin resistance and central adiposity. The aim of the study was to evaluation of influence of the oral contraceptive pill on the endocrinologic and metabolic parameters in women with PCOS. Material & methods: Forty nine PCOS women (aged 23,9±3,5 [mean±SD]) without any other diseases were included into the study. Oral contraceptives (0,02mg ethynylestradiol +0,15 mg desogestrel) were administered for 6 months. Hormonal and biochemical analyses were performed with specific assays at the beginning and after 6 month-therapy. BMI, insulin sensitivity index (ISI) and QUICKI were calculated. Statistical analysis was performed using Results: All patients completed 6-month therapy and no severe side effects were reported during the study. A significant reduction in testosterone (T) concentrations was observed (p<0.005). We recorded a significant increase in lipid concentrations. Conclusions: The administration of oral contraceptives in our study group caused decrease in the testosterone level but negative effect on total cholesterol and triglycerides level was observed.
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Keywords

polycystic ovary syndrome, hyperandrogenism, low-dose oral contraceptives, Desogestrel

About this article
Title

The influence of low-dose oral contraceptive pill on clinical and metabolic parameters in young women with polycystic ovary syndrome

Journal

Ginekologia Polska

Issue

Vol 82, No 6 (2011)

Bibliographic record

Ginekol Pol 2011;82(6).

Keywords

polycystic ovary syndrome
hyperandrogenism
low-dose oral contraceptives
Desogestrel

Authors

Beata Banaszewska
Robert Z. Spaczyński
Katarzyna Ożegowska
Leszek Pawelczyk

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