Vol 82, No 7 (2011)

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Gap junction intercellular communication in carcinogenesis of endometrial cancer

Marek Baltaziak, Luiza Kańczuga-Koda, Ryszard Rutkowski, Marcin Musiatowicz, Mariusz Koda, Ryszard Leśniewicz, Urszula Sulkowska, Monika Baltaziak, Tomasz Leśniewicz, Stanisław Sulkowski
Ginekol Pol 2011;82(7).


Abstract One of the mechanisms for direct cell to cell signaling is mediated by gap junctions. These junctions are formed by connexins, transmembrane proteins. Gap junction intercellular communication (GJIC) plays a critical role in tissue development, differentiation of cells, and regulation of tissue homeostasis. Cancer cells are characterized by growth and/or differentiation disorders. Endometrial cancer is the most common gynecological malignancy in developed countries. In this study, we discuss the putative role of GJIC and adhesion molecules in the development of endometrial cancer. The relationships of GJIC to the process of apoptosis and function of some adhesion proteins have also been underlined.

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