Vol 82, No 10 (2011)
ARTICLES
Endometrioid endometrial cancer – the prognostic value of selected clinical and pathological parameters
Leszek Gottwald, Justyna Chałubińska, Małgorzata Moszyńska-Zielińska, Janusz Piekarski, Wiesław Tyliński, Jarosław Szwalski, Robert Kubiak, Grażyna Pasz-Walczak, Katarzyna Hendzel, Aleksandra Ciałkowska-Rysz
Vol 82, No 10 (2011)
ARTICLES
Abstract
Objectives: to assess the relationship between selected clinical and pathological factors and disease free survival (DFS) and overall survival (OS) in endometrioid endometrial cancer patients. Material and methods: A retrospective review of 262 patients aged 37-86 (6.0±9.0) was performed. Selected clinical and pathological data were correlated with DFS and OS. Results: Follow-up was 8-123 months (64.9±27.1). In 4 patients (1.5%) clinical progression was diagnosed during the treatment. In 43 patients (16.4%) relapse was diagnosed 2-61 months (23.9±15.7) after commencing treatment. DFS and OS were 82.1% and 81.3% respectively. In univariate analysis worse DFS was related to older patients (p=0.007) and non-radical surgery (p<0.001). In multivariate analysis worse DFS was related to older patients (HR=1.058; 95%CI=1.024-1.093; p<0.001), younger at menopause (HR=0.910; 95%CI=0.851-0.973;p=0.006), with higher staging (HR=2.639; 95%CI=1.968-3.539; p<0.001) operated non-radically (HR=0.220;95%CI=0.096-0.504; p<0.001). In univariate analysis worse OS was connected with older patients (p=0.018), diabetes type II (p=0.019) and non-radical surgery (p<0.001). In multivariate analysis worse OS was related to younger age at menopause (HR=0.932; 95%CI=0.873-0.996; p=0.039), diabetes type II (HR=2.372; 95%CI=1.260-4.466; p=0.008), higher staging (HR=2.053; 95%CI=1.482-2.845; p<0.001), and non-radical surgery (HR=0.240;95%CI=0.091-0.636; p=0.004). Conclusions: Relapsed endometrial cancer developed in 90.7% during four years after commencing treatment. In 79.1% of these patients distant metastases were present. Most significant prognostic factors were radicality of surgery, age of patients and staging. The presence of diabetes type II and early menopause were connected with worse prognosis.
Abstract
Objectives: to assess the relationship between selected clinical and pathological factors and disease free survival (DFS) and overall survival (OS) in endometrioid endometrial cancer patients. Material and methods: A retrospective review of 262 patients aged 37-86 (6.0±9.0) was performed. Selected clinical and pathological data were correlated with DFS and OS. Results: Follow-up was 8-123 months (64.9±27.1). In 4 patients (1.5%) clinical progression was diagnosed during the treatment. In 43 patients (16.4%) relapse was diagnosed 2-61 months (23.9±15.7) after commencing treatment. DFS and OS were 82.1% and 81.3% respectively. In univariate analysis worse DFS was related to older patients (p=0.007) and non-radical surgery (p<0.001). In multivariate analysis worse DFS was related to older patients (HR=1.058; 95%CI=1.024-1.093; p<0.001), younger at menopause (HR=0.910; 95%CI=0.851-0.973;p=0.006), with higher staging (HR=2.639; 95%CI=1.968-3.539; p<0.001) operated non-radically (HR=0.220;95%CI=0.096-0.504; p<0.001). In univariate analysis worse OS was connected with older patients (p=0.018), diabetes type II (p=0.019) and non-radical surgery (p<0.001). In multivariate analysis worse OS was related to younger age at menopause (HR=0.932; 95%CI=0.873-0.996; p=0.039), diabetes type II (HR=2.372; 95%CI=1.260-4.466; p=0.008), higher staging (HR=2.053; 95%CI=1.482-2.845; p<0.001), and non-radical surgery (HR=0.240;95%CI=0.091-0.636; p=0.004). Conclusions: Relapsed endometrial cancer developed in 90.7% during four years after commencing treatment. In 79.1% of these patients distant metastases were present. Most significant prognostic factors were radicality of surgery, age of patients and staging. The presence of diabetes type II and early menopause were connected with worse prognosis.
Keywords
endometrial adenocarcinoma, endometrioid carcinoma, prognostic factors, overall survival
Title
Endometrioid endometrial cancer – the prognostic value of selected clinical and pathological parameters
Journal
Ginekologia Polska
Issue
Vol 82, No 10 (2011)
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573
Article views/downloads
1410
Bibliographic record
Ginekol Pol 2011;82(10).
Keywords
endometrial adenocarcinoma
endometrioid carcinoma
prognostic factors
overall survival
Authors
Leszek Gottwald
Justyna Chałubińska
Małgorzata Moszyńska-Zielińska
Janusz Piekarski
Wiesław Tyliński
Jarosław Szwalski
Robert Kubiak
Grażyna Pasz-Walczak
Katarzyna Hendzel
Aleksandra Ciałkowska-Rysz
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