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Vol 82, No 12 (2011)
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Importance of CYP1A1 polymorphism and its transcriptional regulation in ovarian and endometrial cancer

Przemysław M. Mrozikiewicz, Edmund Grześkowiak, Agnieszka Seremak-Mrozikiewicz, Anna Bogacz, Magdalena Barlik, Andrzej Semczuk, Joanna Bartkowiak-Wieczorek, Krzysztof Drews
Ginekol Pol 2011;82(12).

open access

Vol 82, No 12 (2011)
ARTICLES

Abstract

Abstract Human cytochrome P450 1A1 is one of the most important enzymes participating in human carcinogenesis because it metabolites several procarcinogens to active carcinogenic metabolites. Additionally, enzymes of CYP450 family play an important role in estrogenes catabolization (17-β-estradiol and estron) to intermediate products (2-, 4-hydroxyestradiol and 2-, 4-hydroxyestrone) including CYP1A1 that catalyses hydroxylation to 2-hydroxyestrogens in the endometrium. Derivates of these compounds (4-hydroxyestrogens) are carcinogenic and could induce DNA damage leading to tumour transformation. The presence of CYP1A1 enzyme in genital tract tissues could induce chemical carcinogenesis initiating cancer development. Recent studies also confirmed the role of CYP1A1 in the development of ovarian and endometrial cancer in humans. The presence of mutated CYP1A1 polymorphic variants influencing the CYP1A1 activity could be responsible for different interindividual susceptibility to genital cancers in women.

Abstract

Abstract Human cytochrome P450 1A1 is one of the most important enzymes participating in human carcinogenesis because it metabolites several procarcinogens to active carcinogenic metabolites. Additionally, enzymes of CYP450 family play an important role in estrogenes catabolization (17-β-estradiol and estron) to intermediate products (2-, 4-hydroxyestradiol and 2-, 4-hydroxyestrone) including CYP1A1 that catalyses hydroxylation to 2-hydroxyestrogens in the endometrium. Derivates of these compounds (4-hydroxyestrogens) are carcinogenic and could induce DNA damage leading to tumour transformation. The presence of CYP1A1 enzyme in genital tract tissues could induce chemical carcinogenesis initiating cancer development. Recent studies also confirmed the role of CYP1A1 in the development of ovarian and endometrial cancer in humans. The presence of mutated CYP1A1 polymorphic variants influencing the CYP1A1 activity could be responsible for different interindividual susceptibility to genital cancers in women.

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Keywords

cytochrome P450, endometrial cancer, cancer, Ovarian, Polymorphism

About this article
Title

Importance of CYP1A1 polymorphism and its transcriptional regulation in ovarian and endometrial cancer

Journal

Ginekologia Polska

Issue

Vol 82, No 12 (2011)

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731

Article views/downloads

1035

Bibliographic record

Ginekol Pol 2011;82(12).

Keywords

cytochrome P450
endometrial cancer
cancer
Ovarian
Polymorphism

Authors

Przemysław M. Mrozikiewicz
Edmund Grześkowiak
Agnieszka Seremak-Mrozikiewicz
Anna Bogacz
Magdalena Barlik
Andrzej Semczuk
Joanna Bartkowiak-Wieczorek
Krzysztof Drews

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