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Vol 83, No 3 (2012)
ARTICLES
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Therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy

Ewa Gulczyńska, Janusz Gadzinowski
Ginekol Pol 2012;83(3).

open access

Vol 83, No 3 (2012)
ARTICLES

Abstract

Hypoxia-ischemia in the perinatal period is a serious condition affecting infants, which can result in death and cerebral palsy and associated disabilities. There has been significant research progress in hypoxic-ischemic encephalopathy over the last 2 decades. Many new molecular mechanisms of asphyxia have been identified. Despite all these advances, therapeutic interventions in HIE remain to be limited. Recently it has been revealed that mild therapeutic hypothermia is the only modality shown to improve neurologic outcome. The authors present a summary of pathogenesis of HIE, animal studies of cooling for hypoxic and ischemic models, and first publications on human therapeutic hypothermia trials. The diagnosis of encephalopathy in full-term neonates and enrollment criteria for hypothermia are also discussed. The current data from randomized control trials of hypothermia as neuroprotection for full and near-term infants are presented along with the results of metaanalyses of these trials. Finally, the status of ongoing neonatal hypothermia trials as well as status of therapeutic hypothermia in Poland is summarized.

Abstract

Hypoxia-ischemia in the perinatal period is a serious condition affecting infants, which can result in death and cerebral palsy and associated disabilities. There has been significant research progress in hypoxic-ischemic encephalopathy over the last 2 decades. Many new molecular mechanisms of asphyxia have been identified. Despite all these advances, therapeutic interventions in HIE remain to be limited. Recently it has been revealed that mild therapeutic hypothermia is the only modality shown to improve neurologic outcome. The authors present a summary of pathogenesis of HIE, animal studies of cooling for hypoxic and ischemic models, and first publications on human therapeutic hypothermia trials. The diagnosis of encephalopathy in full-term neonates and enrollment criteria for hypothermia are also discussed. The current data from randomized control trials of hypothermia as neuroprotection for full and near-term infants are presented along with the results of metaanalyses of these trials. Finally, the status of ongoing neonatal hypothermia trials as well as status of therapeutic hypothermia in Poland is summarized.
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Keywords

newborn, selective head cooling, whole body cooling, hypoxic-ischemic encephalopathy

About this article
Title

Therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy

Journal

Ginekologia Polska

Issue

Vol 83, No 3 (2012)

Bibliographic record

Ginekol Pol 2012;83(3).

Keywords

newborn
selective head cooling
whole body cooling
hypoxic-ischemic encephalopathy

Authors

Ewa Gulczyńska
Janusz Gadzinowski

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