The relationship between selected biochemical parameters, clinical factors and bone mineral density in postmenopausal women with osteoporosis

Abstract

Bone loss in women occurs mainly due to postmenopausal estrogen deficiency and impaired balance between bone resorption by osteoclasts and bone formation by osteoblasts. Objective: The aim of this study was to determine the relationship between selected biochemical parameters, bone turnover markers, clinical parameters and bone mineral density (BMD) in postmenopausal women with osteoporosis. Material and methods: The study group consisted of 85 women treated at the Menopause and Osteoporosis Clinic of the Obstetrics and Gynecological Hospital in Poznań. The average age of the women was 59.9±5.20 years. Quantitative assessment of bone mass at the lumbar spine and proximal femoral epiphysis was performed using DEXA technique. The study included women with BMD expressed as T-score ≤ (-2.5) SD. A multifactorial regression analysis was used to determine the correlation between selected biochemical parameters, clinical factors and BMD. Results: As far as biochemical parameters were concerned, the concentration of estradiol correlated with BMD. The assessed bone turnover markers did not show a correlation with BMD. The following clinical parameters correlated with BMD: age, body mass index - BMI, family history of fractures, bisphosphonates treatment, transdermal hormone replacement therapy use, and intensity of physical activity. Conclusion: It is important to identify risk factors for osteoporosis in women, especially when planning prevention of bone loss in postmenopausal women.