Vol 83, No 6 (2012)
ARTICLES
Smooth muscle tumor of uncertain malignant potential (STUMP) – clinico-pathomorphological analysis of the cases and literature review
Anna Dańska-Bidzińska, Elwira Bakuła-Zalewska, Anna Nasierowska-Guttmejer, Magdalena Kowalewska, Edyta Barnaś, Piotr Sobiczewski, Mariusz Bidziński
Vol 83, No 6 (2012)
ARTICLES
Abstract
Objectives: This retrospective study was designed to evaluate the clinical and pathological features and outcomes of patients diagnosed with uterine smooth muscle tumor of uncertain malignant potential (STUMP). Material and methods: Ten patients diagnosed with uterine STUMP and seen between 2008 and 2011 at the Memorial Cancer Center – Institute of Oncology in Warsaw were identified using the institution databases. Variables of interest included histopathological details, age at diagnosis, types of treatment and recurrence rate. Results: The mean age at diagnosis was 41 years (range 25–56 years). The mean follow-up time was 16 months (range 4–29 months). Diameter of the tumors ranged from 3 to 29 cm. Uterine bleeding was the second most frequent symptom observed in this cohort. In three cases conservative procedure was performed, whereas in other patients hysterectomy was performed. No recurrence was observed during the follow-up period. In all tumors mitoses were less than 10 per 10/hpf, atypia of middle or severe type, and in 3 cases necrosis was observed. In half of the tumors expression of TP53 was found, and value of MIB 1 was estimated at 2-35%. Conclusions: STUMP should be diagnosed by experienced pathologists due to the fact that they are often misdiagnosed as leiomyosarcomas. Clinical behavior of these tumors allows to consider a conservative management in patients wishing to preserve fertility.
Abstract
Objectives: This retrospective study was designed to evaluate the clinical and pathological features and outcomes of patients diagnosed with uterine smooth muscle tumor of uncertain malignant potential (STUMP). Material and methods: Ten patients diagnosed with uterine STUMP and seen between 2008 and 2011 at the Memorial Cancer Center – Institute of Oncology in Warsaw were identified using the institution databases. Variables of interest included histopathological details, age at diagnosis, types of treatment and recurrence rate. Results: The mean age at diagnosis was 41 years (range 25–56 years). The mean follow-up time was 16 months (range 4–29 months). Diameter of the tumors ranged from 3 to 29 cm. Uterine bleeding was the second most frequent symptom observed in this cohort. In three cases conservative procedure was performed, whereas in other patients hysterectomy was performed. No recurrence was observed during the follow-up period. In all tumors mitoses were less than 10 per 10/hpf, atypia of middle or severe type, and in 3 cases necrosis was observed. In half of the tumors expression of TP53 was found, and value of MIB 1 was estimated at 2-35%. Conclusions: STUMP should be diagnosed by experienced pathologists due to the fact that they are often misdiagnosed as leiomyosarcomas. Clinical behavior of these tumors allows to consider a conservative management in patients wishing to preserve fertility.
Keywords
smooth muscle tumors, histopathology, diagnosis, treatment
Title
Smooth muscle tumor of uncertain malignant potential (STUMP) – clinico-pathomorphological analysis of the cases and literature review
Journal
Ginekologia Polska
Issue
Vol 83, No 6 (2012)
Page views
1150
Article views/downloads
8767
Bibliographic record
Ginekol Pol 2012;83(6).
Keywords
smooth muscle tumors
histopathology
diagnosis
treatment
Authors
Anna Dańska-Bidzińska
Elwira Bakuła-Zalewska
Anna Nasierowska-Guttmejer
Magdalena Kowalewska
Edyta Barnaś
Piotr Sobiczewski
Mariusz Bidziński
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