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Vol 83, No 7 (2012)
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Survivin – prognostic tumor biomarker in human neoplasms – review

Joanna Waligórska-Stachura, Anna Jankowska, Ryszard Waśko, Wlodzimierz Liebert, Maciej Biczysko, Agata Czarnywojtek, Daria Baszko-Błaszyk, Violet Shimek, Marek Ruchała
Ginekol Pol 2012;83(7).

open access

Vol 83, No 7 (2012)
ARTICLES

Abstract

Accurate diagnosis and proper monitoring of cancer patients remain important obstacles for successful cancer treatment. The search for cancer biomarkers is carried out in order to quickly identify tumor cells and predict treatment response, ultimately leading to a favorable therapeutic outcome. One such prognostic marker seems to be survivin. Many studies have shown that survivin is strongly expressed in a vast majority of cancers. Its overexpression was demonstrated in breast and lung cancer, prostate, gastric, colon, bladder, and esophageal carcinomas, osteosarcomas, and lymphomas. In many of those tumors, high activity of the survivin gene was associated with a poor prognosis and worse survival rates. Moreover, survivin expression was correlated with resistance to chemotherapy and radiotherapy-induced apoptosis. Since survivin may be identified as an independent prognostic factor and inhibitor of apoptosis, it may prove to be a useful therapeutic target in cancer therapy.

Abstract

Accurate diagnosis and proper monitoring of cancer patients remain important obstacles for successful cancer treatment. The search for cancer biomarkers is carried out in order to quickly identify tumor cells and predict treatment response, ultimately leading to a favorable therapeutic outcome. One such prognostic marker seems to be survivin. Many studies have shown that survivin is strongly expressed in a vast majority of cancers. Its overexpression was demonstrated in breast and lung cancer, prostate, gastric, colon, bladder, and esophageal carcinomas, osteosarcomas, and lymphomas. In many of those tumors, high activity of the survivin gene was associated with a poor prognosis and worse survival rates. Moreover, survivin expression was correlated with resistance to chemotherapy and radiotherapy-induced apoptosis. Since survivin may be identified as an independent prognostic factor and inhibitor of apoptosis, it may prove to be a useful therapeutic target in cancer therapy.

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Keywords

survivin, Tumor biomarker, neoplasms

About this article
Title

Survivin – prognostic tumor biomarker in human neoplasms – review

Journal

Ginekologia Polska

Issue

Vol 83, No 7 (2012)

Page views

978

Article views/downloads

1109

Bibliographic record

Ginekol Pol 2012;83(7).

Keywords

survivin
Tumor biomarker
neoplasms

Authors

Joanna Waligórska-Stachura
Anna Jankowska
Ryszard Waśko
Wlodzimierz Liebert
Maciej Biczysko
Agata Czarnywojtek
Daria Baszko-Błaszyk
Violet Shimek
Marek Ruchała

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