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Vol 83, No 7 (2012)
ARTICLES
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Efects of hormone replacement and tamoxifen on depression in ovariectomized rats

Mustafa Cosan Terek, Lutfiye Kanit, Yusuf Hakan Dogan, Oguz Gozen, Burak Zeybek, Aysegul Keser, Serdar Ozsener, Sakire Pogun
Ginekol Pol 2012;83(7).

open access

Vol 83, No 7 (2012)
ARTICLES

Abstract

Objectives: To determine the effects of tamoxifen and hormone replacement therapy in order to assess their role in depressive behavior. Material and Methods: Different protocols of hormone replacement therapies were administered to surgically ovariectomized rats. Intact rats were used for tamoxifen experiments. Properly assigned control groups were used and cognitive processes were studied on animal models of surgical menopause using the Porsolt Forced Swim Test and locomotor activity experiments. Results: In the tamoxifen experiments, an interaction between treatment and days did not reach statistical significance, but indicated a trend in this direction [F(1,26)=3.557, p=0.071]. The number of repeated movements significantly decreased after the Porsolt test (F(1,44) = 8.483, P<0.006) in the hormone replacement experiments. In the tamoxifen experiments, the number of repeated movements significantly decreased after the Porsolt test (F(1,26) = 74.410, P<0.001). Conclusions: While sequential hormone replacement is found to

Abstract

Objectives: To determine the effects of tamoxifen and hormone replacement therapy in order to assess their role in depressive behavior. Material and Methods: Different protocols of hormone replacement therapies were administered to surgically ovariectomized rats. Intact rats were used for tamoxifen experiments. Properly assigned control groups were used and cognitive processes were studied on animal models of surgical menopause using the Porsolt Forced Swim Test and locomotor activity experiments. Results: In the tamoxifen experiments, an interaction between treatment and days did not reach statistical significance, but indicated a trend in this direction [F(1,26)=3.557, p=0.071]. The number of repeated movements significantly decreased after the Porsolt test (F(1,44) = 8.483, P<0.006) in the hormone replacement experiments. In the tamoxifen experiments, the number of repeated movements significantly decreased after the Porsolt test (F(1,26) = 74.410, P<0.001). Conclusions: While sequential hormone replacement is found to
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Keywords

tamoxifen, Hormone replacement, depression, menopause

About this article
Title

Efects of hormone replacement and tamoxifen on depression in ovariectomized rats

Journal

Ginekologia Polska

Issue

Vol 83, No 7 (2012)

Bibliographic record

Ginekol Pol 2012;83(7).

Keywords

tamoxifen
Hormone replacement
depression
menopause

Authors

Mustafa Cosan Terek
Lutfiye Kanit
Yusuf Hakan Dogan
Oguz Gozen
Burak Zeybek
Aysegul Keser
Serdar Ozsener
Sakire Pogun

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