Vol 83, No 12 (2012)
ARTICLES
Prognostic factors in patients with primary invasive vaginal carcinoma
Paweł Blecharz, Marian Reinfuss, Jerzy Jakubowicz, Piotr Skotnicki, Wojciech Wysocki, Kazimierz Karolewski, Krzysztof Urbański
Vol 83, No 12 (2012)
ARTICLES
Abstract
Aim of the study: Aim of the study was the assessment of prognostic factors in the group of primary invasive vaginal carcinoma (PIVC) patients subjected to radical radiation therapy. Material and methods: The analysis was performed for the group of 152 PIVC patients treated with intracavitary brachytherapy alone (16.5%), the combination of brachytherapy and external radiotherapy (78.9%), or external radiotherapy alone (4.6%). The relationship was investigated between treatment outcome and the following demographic, clinical and histopathological features: age, duration of pathological symptoms, number of births given, prior hysterectomy, haemoglobin level, Karnofsky performance status score, primary tumour location in vagina, length of vagina involved, FIGO stage, gross appearance, histological type, and tumour grade. Results: Five-year disease-free survival was observed in 46.1% of the patients (70/152). Patients below 60 years of age, with Karnofsky score of 80-90, diagnosed with PIVC in stage I0 or II0, and with tumour of grade G1 or G2 had significantly higher 5-year disease-free survival. Multifactoral analysis showed that age below 60 and FIGO stage I0 and II0 are independent favourable prognostic factors. Conclusions: The independent prognostic factors in PIVC patients treated with radical radiotherapy are patient age and FIGO stage.
Abstract
Aim of the study: Aim of the study was the assessment of prognostic factors in the group of primary invasive vaginal carcinoma (PIVC) patients subjected to radical radiation therapy. Material and methods: The analysis was performed for the group of 152 PIVC patients treated with intracavitary brachytherapy alone (16.5%), the combination of brachytherapy and external radiotherapy (78.9%), or external radiotherapy alone (4.6%). The relationship was investigated between treatment outcome and the following demographic, clinical and histopathological features: age, duration of pathological symptoms, number of births given, prior hysterectomy, haemoglobin level, Karnofsky performance status score, primary tumour location in vagina, length of vagina involved, FIGO stage, gross appearance, histological type, and tumour grade. Results: Five-year disease-free survival was observed in 46.1% of the patients (70/152). Patients below 60 years of age, with Karnofsky score of 80-90, diagnosed with PIVC in stage I0 or II0, and with tumour of grade G1 or G2 had significantly higher 5-year disease-free survival. Multifactoral analysis showed that age below 60 and FIGO stage I0 and II0 are independent favourable prognostic factors. Conclusions: The independent prognostic factors in PIVC patients treated with radical radiotherapy are patient age and FIGO stage.
Keywords
Vaginal Cancer, radiotherapy, prognostic factors
Title
Prognostic factors in patients with primary invasive vaginal carcinoma
Journal
Ginekologia Polska
Issue
Vol 83, No 12 (2012)
Page views
566
Article views/downloads
738
Bibliographic record
Ginekol Pol 2012;83(12).
Keywords
Vaginal Cancer
radiotherapy
prognostic factors
Authors
Paweł Blecharz
Marian Reinfuss
Jerzy Jakubowicz
Piotr Skotnicki
Wojciech Wysocki
Kazimierz Karolewski
Krzysztof Urbański
About this article