open access

Vol 84, No 2 (2013)
ARTICLES
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Relaxin 2 – a pregnancy hormone involved in the process of carcinogenesis

Kamila Domińska
DOI: 10.17772/gp/1552
·
Ginekol Pol 2013;84(2).

open access

Vol 84, No 2 (2013)
ARTICLES

Abstract

Relaxin 2 is a polypeptide hormone structurally related to insulin and insulin-like growth factors (IGFs). However, it does not interact with insulin receptors and has a decidedly different biological properties. Relaxin 2 activates LGR 7 and LGR 8 relaxin receptors, that belong to the leucine-rich repeat-containing (LRR), G protein-coupled receptors. The characteristic functions of relaxin are associated with female reproductive system, especially during pregnancy. However, recent studies have shown that polypeptides with relaxin-like factor family (RLF) are involved in cell proliferation and differentiation, as well as invasion and angiogenesis of female and male reproductive cancers. This review provides information on the structure and function of relaxin and its receptors. Furthermore, we present evidence of the involvement of these elements in the process of cancerogenesis.

Abstract

Relaxin 2 is a polypeptide hormone structurally related to insulin and insulin-like growth factors (IGFs). However, it does not interact with insulin receptors and has a decidedly different biological properties. Relaxin 2 activates LGR 7 and LGR 8 relaxin receptors, that belong to the leucine-rich repeat-containing (LRR), G protein-coupled receptors. The characteristic functions of relaxin are associated with female reproductive system, especially during pregnancy. However, recent studies have shown that polypeptides with relaxin-like factor family (RLF) are involved in cell proliferation and differentiation, as well as invasion and angiogenesis of female and male reproductive cancers. This review provides information on the structure and function of relaxin and its receptors. Furthermore, we present evidence of the involvement of these elements in the process of cancerogenesis.
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Keywords

carcinogenesis, relaxin 2, LGR8, LGR7

About this article
Title

Relaxin 2 – a pregnancy hormone involved in the process of carcinogenesis

Journal

Ginekologia Polska

Issue

Vol 84, No 2 (2013)

DOI

10.17772/gp/1552

Bibliographic record

Ginekol Pol 2013;84(2).

Keywords

carcinogenesis
relaxin 2
LGR8
LGR7

Authors

Kamila Domińska

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