open access

Vol 84, No 3 (2013)
ARTICLES
Get Citation

Selected polymorphisms of Renin-Angiotensin System in the pathology of hypertensive disorders of pregnancy

Katarzyna Kuśmierska-Urban, Krzysztof Rytlewski, Alfred Reroń
DOI: 10.17772/gp/1566
·
Ginekol Pol 2013;84(3).

open access

Vol 84, No 3 (2013)
ARTICLES

Abstract

Pregnancy induced hypertension and pre-eclampsia, defined as hypertension and proteinuria after 20 weeks of pregnancy, with no history of such symptoms, are a great challenge in the field of perinatology. They are a serious threat to the mother and the child. Regardless of numerous studies on the subject, the pathogenesis of pregnancyinduced hypertension and pre-eclampsia is still unknown, although a crucial role of genetic factors combined with environmental factors has been confirmed. New theory, based on genetic analysis of Renin-Angiotensin System and its impact on blood pressure in pregnant women, has been subject to much debate recently. Numerous genes have been studied but angiotensinogen remains to be the best known. Little is known about angiotensin receptor type 1 and 2. This paper presents the knowledge about selected genes of RAS and their impact on pregnancy.

Abstract

Pregnancy induced hypertension and pre-eclampsia, defined as hypertension and proteinuria after 20 weeks of pregnancy, with no history of such symptoms, are a great challenge in the field of perinatology. They are a serious threat to the mother and the child. Regardless of numerous studies on the subject, the pathogenesis of pregnancyinduced hypertension and pre-eclampsia is still unknown, although a crucial role of genetic factors combined with environmental factors has been confirmed. New theory, based on genetic analysis of Renin-Angiotensin System and its impact on blood pressure in pregnant women, has been subject to much debate recently. Numerous genes have been studied but angiotensinogen remains to be the best known. Little is known about angiotensin receptor type 1 and 2. This paper presents the knowledge about selected genes of RAS and their impact on pregnancy.
Get Citation

Keywords

preeclampsia, Polymorphisms, pregnancy induced hypertension

About this article
Title

Selected polymorphisms of Renin-Angiotensin System in the pathology of hypertensive disorders of pregnancy

Journal

Ginekologia Polska

Issue

Vol 84, No 3 (2013)

DOI

10.17772/gp/1566

Bibliographic record

Ginekol Pol 2013;84(3).

Keywords

preeclampsia
Polymorphisms
pregnancy induced hypertension

Authors

Katarzyna Kuśmierska-Urban
Krzysztof Rytlewski
Alfred Reroń

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk
tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl