Vol 84, No 6 (2013)

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Multiplex Ligation-dependent Probe Amplification (MLPA) – new possibilities of prenatal diagnosis

Diana Massalska, Julia Bijok, Grzegorz Jakiel, Tomasz Roszkowski, Janusz G. Zimowski, Anna Jóźwiak
DOI: 10.17772/gp/1605
Ginekol Pol 2013;84(6).


Multiplex Ligation-dependent Probe Amplification (MLPA) is a relatively new method of molecular diagnosis. It enables a relative quantitative assessment of up to 50 different PCR amplicons in one reaction by the use of a very small amount of examined DNA. Nowadays MLPA is becoming a very helpful tool in prenatal diagnosis and is widely used for the detection of aneuploidies, familial single gene disorders, common microdeletion syndromes, sub-telomeric alterations and identification of marker chromosomes in fetuses. This review demonstrates possible applications of MLPA in prenatal diagnosis.

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