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Vol 84, No 6 (2013)
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Transabdominal chorionic villus sampling (CVS) for prenatal diagnosis of chromosomal disorders – own experiences

Marcin Sodowski, Krzysztof Sodowski, Henryka Sodowska, Agnieszka Kania, Jolanta Hadaś, Agnieszka Gnyś-Wiercioch, Renata Bloch, Barbara Grolik, Mariola Szołtysik-Szot, Wojciech Cnota
DOI: 10.17772/gp/1597
·
Ginekol Pol 2013;84(6).

open access

Vol 84, No 6 (2013)
ARTICLES

Abstract

Objective: To present the authors’ own experiences on transabdominal Chorionic Villus Sampling (CVS) for prenatal diagnosis of genetic disorders. Design: Descriptive study. Patiens and methods: A total of 290 couples with request for prenatal diagnosis of various genetic disorders were studied. The most common indications were: fetal abnormalities suspected in an ultrasound scan and biochemistry, positive family history on genetic disorders, maternal age. Transabdominal CVS was done under local anesthesia and ultrasound guidance. The genetic analysis was possible in 264 cases (241 with abnormal ultrasound scan and/or biochemistry, 11 with positive family history, 12 with maternal age). Results were recorded and analyzed for descriptive statistics. Result: A total of 290 CVSs were done in the outdoor. Most procedures (76%) were done between 12 and 14 weeks (range 11-16 weeks). All placental positions including both anterior and posterior were approachable through the trans-abdominal route. The overall success rate was 100%. Abnormal fetal karyotype was diagnosed in 39% of cases. In 12.9% of cases inconclusive results were observed (due to placental mosaicism or maternal cells contamination). More aneuploidies were observed in group with abnormal first trimester screening (us scan and/or biochemistry) compared to any other indications. Conclusion: Transabdominal CVS is a useful outdoor procedure for prenatal diagnosis. However indications for the procedure should be carefully considered since some risk of inconclusive results occurred.

Abstract

Objective: To present the authors’ own experiences on transabdominal Chorionic Villus Sampling (CVS) for prenatal diagnosis of genetic disorders. Design: Descriptive study. Patiens and methods: A total of 290 couples with request for prenatal diagnosis of various genetic disorders were studied. The most common indications were: fetal abnormalities suspected in an ultrasound scan and biochemistry, positive family history on genetic disorders, maternal age. Transabdominal CVS was done under local anesthesia and ultrasound guidance. The genetic analysis was possible in 264 cases (241 with abnormal ultrasound scan and/or biochemistry, 11 with positive family history, 12 with maternal age). Results were recorded and analyzed for descriptive statistics. Result: A total of 290 CVSs were done in the outdoor. Most procedures (76%) were done between 12 and 14 weeks (range 11-16 weeks). All placental positions including both anterior and posterior were approachable through the trans-abdominal route. The overall success rate was 100%. Abnormal fetal karyotype was diagnosed in 39% of cases. In 12.9% of cases inconclusive results were observed (due to placental mosaicism or maternal cells contamination). More aneuploidies were observed in group with abnormal first trimester screening (us scan and/or biochemistry) compared to any other indications. Conclusion: Transabdominal CVS is a useful outdoor procedure for prenatal diagnosis. However indications for the procedure should be carefully considered since some risk of inconclusive results occurred.

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Keywords

Fetal Karyotype, prenatal diagnosis, chorion villus sampling

About this article
Title

Transabdominal chorionic villus sampling (CVS) for prenatal diagnosis of chromosomal disorders – own experiences

Journal

Ginekologia Polska

Issue

Vol 84, No 6 (2013)

Page views

715

Article views/downloads

3114

DOI

10.17772/gp/1597

Bibliographic record

Ginekol Pol 2013;84(6).

Keywords

Fetal Karyotype
prenatal diagnosis
chorion villus sampling

Authors

Marcin Sodowski
Krzysztof Sodowski
Henryka Sodowska
Agnieszka Kania
Jolanta Hadaś
Agnieszka Gnyś-Wiercioch
Renata Bloch
Barbara Grolik
Mariola Szołtysik-Szot
Wojciech Cnota

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