Vol 84, No 7 (2013)
ARTICLES
Comparison of two doses of recombinant hcg for oocyte maturation in obese women (BMI ≥30) undergoing assisted reproductive techniques
Semra Kahrama, Mustecep Kavrut
DOI: 10.17772/gp/1611
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Ginekol Pol 2013;84(7).
Vol 84, No 7 (2013)
ARTICLES
Abstract
Objective: To compare the efficacy of two doses (250 μg vs. 500 μg) of r-hCG for oocyte maturation in obese women with a body mass index (BMI) ≥30 and undergoing assisted reproduction techniques. Materıals and Methods: A Prospective, randomized, clinical study of seventy two patients undergoing IVF/ intracytoplasmic sperm injection cycles with BMI ≥30 kg/m2. Patients with high BMI were randomized to receive either 250 μg or 500 μg rhCG. Blood and follicular fluid (FF) samples were collected on the day of oocyte pick-up (OPU). The outcome measures were serum and FF hCG levels on the day of OPU, number of oocytes retrieved per patient, number of mature oocytes retrieved, clinical pregnancy rates (PR). Results: Serum hCG levels were significantly lower in patients receiving 250 μg of r-hCG than in patients receiving 500 μg of r-hCG. However FF hCG levels, implantation rates, abortion rates, clinical PRs were not significantly different. Conclusions: 250 μg of r-hCG is sufficient and safe to trigger ovulation in women with BMI ≥30.
Abstract
Objective: To compare the efficacy of two doses (250 μg vs. 500 μg) of r-hCG for oocyte maturation in obese women with a body mass index (BMI) ≥30 and undergoing assisted reproduction techniques. Materıals and Methods: A Prospective, randomized, clinical study of seventy two patients undergoing IVF/ intracytoplasmic sperm injection cycles with BMI ≥30 kg/m2. Patients with high BMI were randomized to receive either 250 μg or 500 μg rhCG. Blood and follicular fluid (FF) samples were collected on the day of oocyte pick-up (OPU). The outcome measures were serum and FF hCG levels on the day of OPU, number of oocytes retrieved per patient, number of mature oocytes retrieved, clinical pregnancy rates (PR). Results: Serum hCG levels were significantly lower in patients receiving 250 μg of r-hCG than in patients receiving 500 μg of r-hCG. However FF hCG levels, implantation rates, abortion rates, clinical PRs were not significantly different. Conclusions: 250 μg of r-hCG is sufficient and safe to trigger ovulation in women with BMI ≥30.
Keywords
IVF, serum and follicular fluid, obesity, recombinat hCG, Oocyte maturation
Title
Comparison of two doses of recombinant hcg for oocyte maturation in obese women (BMI ≥30) undergoing assisted reproductive techniques
Journal
Ginekologia Polska
Issue
Vol 84, No 7 (2013)
Page views
779
Article views/downloads
1222
DOI
10.17772/gp/1611
Bibliographic record
Ginekol Pol 2013;84(7).
Keywords
IVF
serum and follicular fluid
obesity
recombinat hCG
Oocyte maturation
Authors
Semra Kahrama
Mustecep Kavrut
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