open access

Vol 84, No 7 (2013)
ARTICLES
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Comparison of two doses of recombinant hcg for oocyte maturation in obese women (BMI ≥30) undergoing assisted reproductive techniques

Semra Kahrama, Mustecep Kavrut
DOI: 10.17772/gp/1611
·
Ginekol Pol 2013;84(7).

open access

Vol 84, No 7 (2013)
ARTICLES

Abstract

Objective: To compare the efficacy of two doses (250 μg vs. 500 μg) of r-hCG for oocyte maturation in obese women with a body mass index (BMI) ≥30 and undergoing assisted reproduction techniques. Materıals and Methods: A Prospective, randomized, clinical study of seventy two patients undergoing IVF/ intracytoplasmic sperm injection cycles with BMI ≥30 kg/m2. Patients with high BMI were randomized to receive either 250 μg or 500 μg rhCG. Blood and follicular fluid (FF) samples were collected on the day of oocyte pick-up (OPU). The outcome measures were serum and FF hCG levels on the day of OPU, number of oocytes retrieved per patient, number of mature oocytes retrieved, clinical pregnancy rates (PR). Results: Serum hCG levels were significantly lower in patients receiving 250 μg of r-hCG than in patients receiving 500 μg of r-hCG. However FF hCG levels, implantation rates, abortion rates, clinical PRs were not significantly different. Conclusions: 250 μg of r-hCG is sufficient and safe to trigger ovulation in women with BMI ≥30.

Abstract

Objective: To compare the efficacy of two doses (250 μg vs. 500 μg) of r-hCG for oocyte maturation in obese women with a body mass index (BMI) ≥30 and undergoing assisted reproduction techniques. Materıals and Methods: A Prospective, randomized, clinical study of seventy two patients undergoing IVF/ intracytoplasmic sperm injection cycles with BMI ≥30 kg/m2. Patients with high BMI were randomized to receive either 250 μg or 500 μg rhCG. Blood and follicular fluid (FF) samples were collected on the day of oocyte pick-up (OPU). The outcome measures were serum and FF hCG levels on the day of OPU, number of oocytes retrieved per patient, number of mature oocytes retrieved, clinical pregnancy rates (PR). Results: Serum hCG levels were significantly lower in patients receiving 250 μg of r-hCG than in patients receiving 500 μg of r-hCG. However FF hCG levels, implantation rates, abortion rates, clinical PRs were not significantly different. Conclusions: 250 μg of r-hCG is sufficient and safe to trigger ovulation in women with BMI ≥30.
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Keywords

IVF, serum and follicular fluid, obesity, recombinat hCG, Oocyte maturation

About this article
Title

Comparison of two doses of recombinant hcg for oocyte maturation in obese women (BMI ≥30) undergoing assisted reproductive techniques

Journal

Ginekologia Polska

Issue

Vol 84, No 7 (2013)

DOI

10.17772/gp/1611

Bibliographic record

Ginekol Pol 2013;84(7).

Keywords

IVF
serum and follicular fluid
obesity
recombinat hCG
Oocyte maturation

Authors

Semra Kahrama
Mustecep Kavrut

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