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Vol 84, No 9 (2013)
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Frequency of G2677T/A and C3435T polymorphisms of MDR1 gene in preeclamptic women

Anna Bogacz, Przemysław M. Mrozikiewicz, Joanna Bartkowiak-Wieczorek, Aleksandra Kowalska, Donata Deka-Pawlik, Edmund Grześkowiak, Agnieszka Seremak-Mrozikiewicz, Magdalena Barlik, Krzysztof Drews
DOI: 10.17772/gp/1640
·
Ginekol Pol 2013;84(9).

open access

Vol 84, No 9 (2013)
ARTICLES

Abstract

Objective: Preeclampsia (PE) belongs to main causes of mortality rates of mothers, fetuses and new born children. Polymorphism of MDR1 gene is connected with reduction of P-glycoprotein expression in placenta and increased fetal exposure to xenobiotics. The aim of the study was to determine the frequency of C3435T and G2677T/A polymorphisms of MDR1 gene in pregnant women with preeclampsia. Materials and methods: The study consisted of 180 Polish women including 60 women with PE and 120 healthy pregnant women. Determination of C3435T and G2677T/A polymorphisms of MDR1 gene was performed using PCR-RFLP method. Results: No significant association between genotypes of the examined polymorphisms and the clinical parameters of pregnant women with PE was observed. However the interesting tendency to higher prevalence of mutated 2677A allele of G2677T/A MDR1 polymorphism in PE group has been shown (2,50 vs. 0,83% in controls, OR=3,05, ns). Conclusions: The results of this study suggest no significant effect of examined C3435T and G2677T/A MDR1 polymorphisms in PE pathogenesis. However given the noteworthy results related to mutated 2677A allele of G2677T/A MDR1 polymorphism in preeclamptic women further studies seem to be needed. Nevertheless, the frequency of investigated polymorphisms was consistent with the distribution in other Caucasian populations.

Abstract

Objective: Preeclampsia (PE) belongs to main causes of mortality rates of mothers, fetuses and new born children. Polymorphism of MDR1 gene is connected with reduction of P-glycoprotein expression in placenta and increased fetal exposure to xenobiotics. The aim of the study was to determine the frequency of C3435T and G2677T/A polymorphisms of MDR1 gene in pregnant women with preeclampsia. Materials and methods: The study consisted of 180 Polish women including 60 women with PE and 120 healthy pregnant women. Determination of C3435T and G2677T/A polymorphisms of MDR1 gene was performed using PCR-RFLP method. Results: No significant association between genotypes of the examined polymorphisms and the clinical parameters of pregnant women with PE was observed. However the interesting tendency to higher prevalence of mutated 2677A allele of G2677T/A MDR1 polymorphism in PE group has been shown (2,50 vs. 0,83% in controls, OR=3,05, ns). Conclusions: The results of this study suggest no significant effect of examined C3435T and G2677T/A MDR1 polymorphisms in PE pathogenesis. However given the noteworthy results related to mutated 2677A allele of G2677T/A MDR1 polymorphism in preeclamptic women further studies seem to be needed. Nevertheless, the frequency of investigated polymorphisms was consistent with the distribution in other Caucasian populations.

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Keywords

preeclampsia, P-glycoprotein, MDR1 gene, Genetic polymorphism

About this article
Title

Frequency of G2677T/A and C3435T polymorphisms of MDR1 gene in preeclamptic women

Journal

Ginekologia Polska

Issue

Vol 84, No 9 (2013)

Page views

702

Article views/downloads

780

DOI

10.17772/gp/1640

Bibliographic record

Ginekol Pol 2013;84(9).

Keywords

preeclampsia
P-glycoprotein
MDR1 gene
Genetic polymorphism

Authors

Anna Bogacz
Przemysław M. Mrozikiewicz
Joanna Bartkowiak-Wieczorek
Aleksandra Kowalska
Donata Deka-Pawlik
Edmund Grześkowiak
Agnieszka Seremak-Mrozikiewicz
Magdalena Barlik
Krzysztof Drews

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