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Vol 84, No 10 (2013)
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Ocular manifestations in a newborn from a pregnancy complicated by an antiphospholipid syndrome – a case report

Monika Modrzejewska, Anna Michalak, Wojciech Lubiński, Olimpia Szmigiel, Lidia Ostanek, Elżbieta Ronin-Walknowska
DOI: 10.17772/gp/1658
·
Ginekol Pol 2013;84(10).

open access

Vol 84, No 10 (2013)
ARTICLES

Abstract

The paper presents a case of ophthalmologic manifestations, episcleritis and retinal branch vein thrombosis, in a neonate born to a mother with antiphospholipid syndrome (APS) in the course of systemic lupus erythematosus. Female neonate (birth weight 1150 g, Apgar scores 6, 7 and 7) was born with respiratory distress syndrome, moderate anemia and grades I and II intraventricular hemorrhage. Ophthalmic examination revealed an enormous pre-retinal hemorrhage with accompanying thrombotic changes typical of retinal vein in the fundus of the left eye. Episcleritis was found in the anterior segment of the eye and later confirmed by ultrasound. Laboratory tests showed increased levels of maternal antibodies aCL IgG, antyβ2GP1 IgG and antyβ2GP1 IgM. No ANA, LA and SS-A/SS-B antibodies were detected. Increased concentrations of aCL IgG and a lengthening APTT were observed in newborn blood at first but the parameters normalized by 6 months of age. Our observations allowed us to conclude that early examination of neonates born to mothers with antiphospholipid syndrome is essential as it allows fast identification of pathological retinal changes by means of assessing the presence of aPL antibodies.

Abstract

The paper presents a case of ophthalmologic manifestations, episcleritis and retinal branch vein thrombosis, in a neonate born to a mother with antiphospholipid syndrome (APS) in the course of systemic lupus erythematosus. Female neonate (birth weight 1150 g, Apgar scores 6, 7 and 7) was born with respiratory distress syndrome, moderate anemia and grades I and II intraventricular hemorrhage. Ophthalmic examination revealed an enormous pre-retinal hemorrhage with accompanying thrombotic changes typical of retinal vein in the fundus of the left eye. Episcleritis was found in the anterior segment of the eye and later confirmed by ultrasound. Laboratory tests showed increased levels of maternal antibodies aCL IgG, antyβ2GP1 IgG and antyβ2GP1 IgM. No ANA, LA and SS-A/SS-B antibodies were detected. Increased concentrations of aCL IgG and a lengthening APTT were observed in newborn blood at first but the parameters normalized by 6 months of age. Our observations allowed us to conclude that early examination of neonates born to mothers with antiphospholipid syndrome is essential as it allows fast identification of pathological retinal changes by means of assessing the presence of aPL antibodies.

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Keywords

antiphospholipid antibodies, connective tissue disorders, complications pregnancy, newborn, episcleritis, retinal branch vein thrombosis, thrombosis risk factors

About this article
Title

Ocular manifestations in a newborn from a pregnancy complicated by an antiphospholipid syndrome – a case report

Journal

Ginekologia Polska

Issue

Vol 84, No 10 (2013)

Page views

657

Article views/downloads

950

DOI

10.17772/gp/1658

Bibliographic record

Ginekol Pol 2013;84(10).

Keywords

antiphospholipid antibodies
connective tissue disorders
complications pregnancy
newborn
episcleritis
retinal branch vein thrombosis
thrombosis risk factors

Authors

Monika Modrzejewska
Anna Michalak
Wojciech Lubiński
Olimpia Szmigiel
Lidia Ostanek
Elżbieta Ronin-Walknowska

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