open access

Vol 84, No 10 (2013)
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The 20210G > A and 19911A > G polymorphisms of prothrombin gene and recurrent miscarriages

Magdalena Barlik, Agnieszka Seremak-Mrozikiewicz, Witold Kraśnik, Krzysztof Drews
DOI: 10.17772/gp/1647
·
Ginekol Pol 2013;84(10).

open access

Vol 84, No 10 (2013)
ARTICLES

Abstract

Objectives: The aim of the study was to evaluate the frequency of 20210G>A and 19911A>G prothrombin gene polymorphisms in a group of women with 2 or more miscarriages in the first trimester of pregnancy. Material and methods: The study involved 150 women with two or more miscarriages in the first trimester of pregnancy (mean age 31.5±4.1 years). The control group consisted of 180 healthy women (mean age 28.7±4.0 years). The frequency of genotypes and alleles of the investigated polymorphisms was evaluated by polymerase chain reaction/restriction fragments length polymorphism method (PCR/RFLP). Results: As to the 20210G>A prothrombin gene polymorphism, overrepresentations of 20210GA genotype have been observed in the group of women with miscarriages (2.7% vs. 1.1% in the control group, WR=2.44, ns), as well as overrepresentation of 20210A allele (1.3% vs. 0.6% in the control group, WR=2.42, ns). Considering the 19911A>G polymorphism, a similar frequency of mutated homozygous 19911GG genotype has been noted (22.6 vs. 21.1% in controls, OR=1.10, ns). Also, frequency of mutated 19911G allele was similar in both investigated groups with miscarriages and controls (48.6% vs. 45.7%, OR=0.89, ns). Conclusions: Our findings suggest lack of correlation of 20210G>A and 19911A>G prothrombin gene polymorphisms with the risk of recurrent miscarriages in the first trimester of pregnancy. Further studies, concerning other genetic variants conditioning inherited thrombophilia and environmental factors influencing the risk of recurrent abortions, are needed. Therefore, further research with more numerous group of women with recurrent miscarriages and taking into account other polymorphisms of thrombophilia and influence of environmental factors is required.

Abstract

Objectives: The aim of the study was to evaluate the frequency of 20210G>A and 19911A>G prothrombin gene polymorphisms in a group of women with 2 or more miscarriages in the first trimester of pregnancy. Material and methods: The study involved 150 women with two or more miscarriages in the first trimester of pregnancy (mean age 31.5±4.1 years). The control group consisted of 180 healthy women (mean age 28.7±4.0 years). The frequency of genotypes and alleles of the investigated polymorphisms was evaluated by polymerase chain reaction/restriction fragments length polymorphism method (PCR/RFLP). Results: As to the 20210G>A prothrombin gene polymorphism, overrepresentations of 20210GA genotype have been observed in the group of women with miscarriages (2.7% vs. 1.1% in the control group, WR=2.44, ns), as well as overrepresentation of 20210A allele (1.3% vs. 0.6% in the control group, WR=2.42, ns). Considering the 19911A>G polymorphism, a similar frequency of mutated homozygous 19911GG genotype has been noted (22.6 vs. 21.1% in controls, OR=1.10, ns). Also, frequency of mutated 19911G allele was similar in both investigated groups with miscarriages and controls (48.6% vs. 45.7%, OR=0.89, ns). Conclusions: Our findings suggest lack of correlation of 20210G>A and 19911A>G prothrombin gene polymorphisms with the risk of recurrent miscarriages in the first trimester of pregnancy. Further studies, concerning other genetic variants conditioning inherited thrombophilia and environmental factors influencing the risk of recurrent abortions, are needed. Therefore, further research with more numerous group of women with recurrent miscarriages and taking into account other polymorphisms of thrombophilia and influence of environmental factors is required.
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Keywords

Recurrent miscarriages, prothrombin gene, Genetic polymorphism

About this article
Title

The 20210G>A and 19911A>G polymorphisms of prothrombin gene and recurrent miscarriages

Journal

Ginekologia Polska

Issue

Vol 84, No 10 (2013)

DOI

10.17772/gp/1647

Bibliographic record

Ginekol Pol 2013;84(10).

Keywords

Recurrent miscarriages
prothrombin gene
Genetic polymorphism

Authors

Magdalena Barlik
Agnieszka Seremak-Mrozikiewicz
Witold Kraśnik
Krzysztof Drews

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